To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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Cell line stably expressing mutant LRRK2 T1348N (KI) (Type: Raw 264.7 macrophages)
Immortalized Cell
RAW 264.7 macrophage cell line expressing a T1348N mutation in LRRK2 knocked into the endogenous mouse LRRK2 protein using zinc-finger nuclease (ZFN)-assisted adeno viral vector (AAV) technology to generate a stable cell line.
Cell line stably expressing mutant LRRK2 G2019S (KI) (Type: Raw 264.7 macrophages)
Immortalized Cell
RAW 264.7 macrophage cell line expressing a G2019S mutation in LRRK2 knocked into the endogenous mouse LRRK2 protein using zinc-finger nuclease (ZFN)-assisted adeno viral vector (AAV) technology to generate a stable cell line.
We were unable to generate this cell line due to technical difficulty and have discontinued production.
Cell line stably expressing mutant LRRK2 D2017A/G2019S (KI) (Type: Raw 264.7 macrophages)
Immortalized Cell
RAW 264.7 macrophage cell line expressing a D2017A and G2019S mutation in LRRK2 knocked into the endogenous mouse LRRK2 protein using zinc-finger nuclease (ZFN)-assisted adeno viral vector (AAV) technology to generate a stable cell line.
We were unable to generate this cell line due to technical difficulty and have discontinued production.
Cathepsin B Protein
Protein
Human Cathepsin B Protein. This protein was generated and shared by Drs Paul Brennan and Karolina Rygiel at Oxford University though the MJFF Sponsored Tools Program.
BAG3 Protein
Protein
Human BAG3 protein. This protein was generated and shared by Drs Paul Brennan and Karolina Rygiel at Oxford University though the MJFF Sponsored Tools Program.
BAC-Alpha Synuclein 120*
Mouse Model
Mice conditionally express mutant human synuclein directed by the human SNCA promoter/enhancer regions on the BAC transgene that produces a C-terminal truncated protein. Model was generated and deposited by X. William Yang at University of California Los Angles through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:028808
BAC-Alpha Synuclein*
Mouse Model
Mice conditionally express wild-type human synuclein directed by the human SNCA promoter/enhancer regions on the BAC transgene. Model was generated and deposited by X. William Yang at University of California Los Angles through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:028806
Auxilin Antibody
Antibody
Rabbit monoclonal antibody directed against human/mouse auxilin for immunostaining applications.
Estimated Availability: Early 2025
ATP13A2 Knockout Mouse*
Mouse Model
Mice carrying a Atp13a2 mutation resulting in disruption of exons 12 through 15 and a portion of exon 16. Model was generated and deposited by Patrick Schultheis at Northern Kentucky University through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:021914
ATP13A2 Antibody
Antibody
Rabbit monoclonal antibody directed against human ATP13A2 for immunoblotting, immunostaining, and immunoprecipitation applications.
Estimated Availability: Early 2026
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic