To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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Alpha-Synuclein A30P/A53T Mouse*
Mouse Model
Transgenic mice expressing double mutant form of human alpha synuclein containing A30P and A53T under the control of the rat tyrosine hydroxylase promoter. Model was generated and deposited by Eric Richfield at Rutger’s University through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:008239
Alpha-Synuclein 1-122 Truncation Antibody
Antibody
Rabbit monoclonal antibody directed against alpha-synuclein truncated at the 122 residue.
Estimated Availability: Early 2025
Alpha-Synuclein 1-119 Truncation Antibody
Antibody
Rabbit monoclonal antibody directed against alpha-synuclein truncated at the 119 residue.
Estimated Availability: Early 2025
Alpha Synuclein Gene Replacement WT (SNCA-GR WT) Mouse*
Mouse Model
Knock-in/knock-out gene replacement model with mouse genomic regions from Snca exchanged for 158 kb of the human SNCA genomic region. Model was donated by Dr. Michael Koob at University of Minnesota, and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:039166
Alpha Synuclein Gene Replacement E46K (SNCA-GR*E46K) Mouse*
Mouse Model
Knock-in/knock-out gene replacement model with mouse genomic regions from Snca exchanged for 158 kb of the human SNCA genomic region including the E46K mutation. Model was donated by Dr. Michael Koob at University of Minnesota, and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:039168
Alpha Synuclein Gene Replacement A53T (SNCA-GR*A53T) Mouse*
Mouse Model
Knock-in/knock-out gene replacement model with mouse genomic regions from Snca exchanged for 158 kb of the human SNCA genomic region including the A53T mutation. Model was donated by Dr. Michael Koob at University of Minnesota, and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:039167
Acid Ceramidase (ASAH1) Antibody
Antibody
Rabbit monoclonal antibody directed against human acid ceramidase for immunocytochemistry and immunoprecipitation applications.
AAV5-CBA-eGFP
Viral Vector
Viral vector (AAV5 serotype) encoding eGFP to serve as a control vector. Produced by the UNC Vector Core.
Characterization data for this viral vector can be found here.
AAV5-CBA-Alpha-Synuclein
Viral Vector
Viral vector (AAV5 serotype) encoding wild-type alpha-synuclein. Produced by the UNC Vector Core. AAV5-CBA-eGFP available as a control in Control section.
Characterization data for this viral vector can be found here.
AAV2-CBA-eGFP
Viral Vector
Viral vector (AAV2 serotype) encoding eGFP to serve as a control vector. Produced by the UNC Vector Core.
Characterization data for this viral vector can be found here.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic