To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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S69R Rab32 KI Mouse
Mouse Model
CRISPR/Cas9 genome targeting strategy to knockin S69R point mutation in the endogenous mouse Rab32 gene (corresponds to the S71R mutation in human Rab32).
Estimated Availability: Early 2025
ROSA26 LRRK2 R1441C Mouse*
Mouse Model
Mice carrying human LRRK2 R144C mutation inserted into the endogenous Gt(ROSA)26Sor locus. Model was generated and deposited by Darren Moore at Van Andel Research Institute through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:026293
ROSA SNCA Knockout Mouse*
Mouse Model
Mice carrying SNCA knockout allele and Gt(ROSA)26Sor Cre reporter allele. Model was generated and deposited by Vladimir Buchman at Cardiff University School of Biosciences through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:028560
ROSA LRRK2 R1441C Mouse*
Mouse Model
Transgenic mice with human LRRK2 R1441C inserted into the endogenous Gt(ROSA)26Sor locus. Model was generated and deposited by Darren Moore at Van Andel Research Institute through the MJFF Sponsored Tools Program (available through cryorecovery).
RILPL2 Antibody
Antibody
Rabbit monoclonal antibody directed against human/mouse RILPL2 for immunoblotting and immunostaining applications.
Estimated Availability: Early 2025
RILPL1 Antibody
Antibody
Mouse monoclonal antibody directed against total rodent/human RILPL1 protein. Suitable for immunoblot, immunoprecipitation, and immunocytochemistry experiments. This antibody is a chimeric mouse IgG2a version of the rabbit anti-RILPL1 antibody (MJF-R41-21, ab302492).
RILPL1 Antibody
Antibody
Rabbit monoclonal antibody directed against total rodent/human RILPL1 protein. Suitable for immunoblot, immunoprecipitation, and immunocytochemistry experiments.
Rat Alpha-Synuclein Monomer Protein for Making Pre-Formed Fibrils
Protein
Full-length rat alpha-synuclein monomeric protein specially formulated to generate pre-formed fibrils. Please note: Validation of the rat alpha-synuclein monomers for making pre-formed fibrils identified a lack of pathology in vitro in mouse primary hippocampal neurons and in vivo in rat. Email tools@michaeljfox.org with questions or for more information.
Rab8 pS111 Phosphospecific Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against Serine111 of the human Rab8 protein (PINK1-related phosphorylation event). Suitable for immunoblot and immunocytochemistry experiments.
Rab 8A ELISA*
Assay
ELISA kit designed for the quantitative measurement of Rab8A protein in human cell and tissue extract samples.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic