To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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PPMI iPSCs
Human iPS Cell
Induced pluripotent stem cell (iPSC) lines are available through the PPMI repository. The repository includes lines from control, idiopathic PD, genetic PD (LRRK2, GBA, SNCA), genetic unaffected carriers (LRRK2, LRRK2/GBA, GBA, SNCA), and prodromal patients. Gene-revertant controls are available for select lines. An inventory of available lines can be found here: https://zenodo.org/records/10607589
PINK1 pT257 Phosphospecific Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against Threonine 257 of human PINK1. Suitable for immunoblot applications.
PINK1 pS228 Phosphospecific Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against Serine 228 of PINK1.
Expected Availability: Early 2025
PINK1 Plasmids
DNA Plasmids
DNA Plasmids encoding various PINK1 cDNA inserts
PINK1 KO Rat*
Rat Model
Homozygous rat knockout of Pink1 (PTEN-induced putative kinase 1) in the Long Evans Hooded rat strain. RRID:RGD_7241054
PINK1 KO Rat
Rat Model
CRISPR/Cas9 genome targeting strategy to knockout PINK1 on a Sprague Dawley rat background.
Estimated Availability: Late 2025
PINK1 Knockout Mouse*
Mouse Model
PINK1 knockout mice with exons 4 through 7 deleted, producing a nonsense mutation at the start of exon 8 due to a reading frame shift. Model was generated and deposited by Jie Shen at Harvard Medical School Brigham and Women’s Hospital through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:017946
PDGFβ-Human Alpha Synuclein (Line D) Mouse*
Mouse Model
Mice express wildtype human alpha synuclein cDNA driven by the platelet derived growth factor, β polypeptide (PDGFB) promoter. Model was developed by Eliezer Masliah and deposited by Robert Rissman at University of California San Diego, and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:038774
Parkin/PINK1 Double KO Rat
Rat Model
Knockout of Parkin and PINK1 in the Long Evans Hooded rat strain.
Parkin/PINK1 Double KO Rat
Rat Model
Breeding of the CRISPR Parkin KO Sprague Dawley rat with the CRISPR PINK1 KO Sprague Dawley rat to create a line with homozygous deletion of both genes.
Estimated Availability: Mid 2026
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic