To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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Oxidized-DJ-1-Specific Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against oxidized DJ-1 protein.
OMP25 Antibody
Antibody
Rabbit monoclonal antibody directed against human/mouse OMP25 for immunoprecipitation of endogenous mitochondria.
Estimated Availability: Late 2025
Oligomeric Alpha-Synuclein Protein*
Protein
Stable oligomeric aggregates of alpha-synuclein protein. Intended for use in biochemical assays (not intended for use in the pre-formed fibril model).
Mouse/Human Total Alpha-Synuclein Assay
Assay
AlphaLISA® SureFire® Ultra™ immunoassay kit for detection of Human and Mouse total alpha-synuclein.
Mouse/Human pS129 Alpha-Synuclein Assay
Assay
AlphaLISA® SureFire® Ultra™ immunoassay kit for detection of Human and Mouse alpha-synuclein phosphorylated at S129 (pS129 aSyn).
Mouse GCase Antibody
Antibody
Rabbit monoclonal antibody directed against mouse GCase for immunostaining applications. Antibody development failed.
Mouse Alpha-Synuclein Plasmid for PFFs
DNA Plasmids
Plasmid used for bacterial expression of mouse monomeric alpha-synuclein for the PFF-compatible protein distributed by Proteos (see Protein section). RRID:Addgene_89075
Mouse Alpha-Synuclein Monomer Protein for Making Pre-Formed Fibrils
Protein
Full-length mouse alpha-synuclein monomeric protein specially formulated to generate pre-formed fibrils. Please note, we recommend this protein for in vitro studies but not for in vivo experiments (the protein is validated for pS129 alpha-synuclein pathology in vitro but in vivo validation failed as robust pS129 alpha-synuclein pathology was not observed). These highly pure proteins are recommended for biochemical studies and can be used to form fibrils, but these fibrils have been found to lack seeding activity.
Note: A protocol for generating pre-formed fibrils from this monomeric protein will be included with each order.
Mouse Alpha-Synuclein Monomer Protein for Making Pre-Formed Fibrils
Protein
Full-length mouse alpha-synuclein monomeric protein specially formulated to generate pre-formed fibrils. Please note, we recommend this protein for in vitro studies but not for in vivo experiments (the protein as validated for pS129 alpha-synuclein pathology in vitro but in vivo validation failed as robust pS129 alpha-synuclein pathology was not observed).
Note: A protocol for generating pre-formed fibrils from this monomeric protein will be included with each order.
*Discontinued for fibrils lack of seeding activity.
Miro1 Antibody (WB)
Antibody
Rabbit monoclonal antibody directed against human/mouse/rat Miro1, validated for use as a detector antibody in immunoblotting applications.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic