To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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GBA D409V Knockin x Thy1-Alpha-Synuclein Mouse
Transgenic mice resulting from the cross between transgenic mice overexpressing the D409V mutant form of GBA (homozygous) and transgenic mice overexpressing wild type human alpha-synuclein directed by the murine Thy-1 promoter (hemizygous).
Generated as part of the Industry Tools Consortium. RRID:IMSR_JAX:029124
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Alpha-Synuclein Aggregation Assay*
High-throughput in vitro assay to detect alpha-synuclein aggregation developed in a dopamine neuron-like cell line of human origin. Available as a fee-for-service assay.
Generated as part of the Industry Tools Consortium.
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Total DJ-1 Antibody
Mouse monoclonal antibody directed against full length DJ-1. Ideal for use in immunoblotting or immunoassays.
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Ubiquitin pS65 Phosphospecific Antibody (WB/ICC/ELISA)
Rabbit monoclonal phosphospecific antibody directed against Serine65 of ubiquitin. Suitable for immunoblot, immunocytochemistry, and ELISA applications.
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AAV2/5-CBh-eBFP
Viral Vector (AAV2/5 serotype) encoding eBFP to be used as a control for the AAv2/5 WT Human alpha-synuclein viral vector. This virus will not be made available as the QC/QA testing shows that it induces undesired inflammation and toxicity. Since stocks are available, groups may send a request for samples to tools@michaeljfox.org and may be granted access after vetting.
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AAV2/5-CBh-Alpha-Synuclein
Viral Vector (AAV2/5 serotype) encoding wild-type human alpha-synuclein. AAV2/5-CBh-empty vector control is available as a control (listed in the Other gene/protein type section) and the AAV-CBh-alpha-synuclein plasmid is available in the Plasmid section.
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HdAd5 3xFLAG-TK
Helper-dependent Adenovirus 5 viral vector with human synapsin promoter driving the expression of 3XFLAG-tagged TK. For use as a control with the HdAd5 3xFLAG-LRRK2 (WT, G2019S, G2385R) viral vectors.
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AAV1/2-CAG-Human SNCA 3xmiR/GFP
CNS optimized viral vector (AAV1/2 pseudotype) encoding GFP and 3XmiR to alpha-synuclein for specific knockdown of WT human a-syn and common pathogenic mutant forms (A53T, A30P, E46K). Scrambled Control 3xSCRmiR/GFP available as a control in Reporter section and AAV Human SNCA 3xmiR/GFP plasmid available in the Plasmid section.
Generated as part of the Industry Tools Consortium.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic