To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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Alpha-Synuclein Aggregation Assay*
High-throughput in vitro assay to detect alpha-synuclein aggregation developed in a dopamine neuron-like cell line of human origin. Available as a fee-for-service assay.
Generated as part of the Industry Tools Consortium.
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Total DJ-1 Antibody
Mouse monoclonal antibody directed against full length DJ-1. Ideal for use in immunoblotting or immunoassays.
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Ubiquitin pS65 Phosphospecific Antibody (WB/ICC/ELISA)
Rabbit monoclonal phosphospecific antibody directed against Serine65 of ubiquitin. Suitable for immunoblot, immunocytochemistry, and ELISA applications.
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AAV2/5-CBh-eBFP
Viral Vector (AAV2/5 serotype) encoding eBFP to be used as a control for the AAv2/5 WT Human alpha-synuclein viral vector. This virus will not be made available as the QC/QA testing shows that it induces undesired inflammation and toxicity. Since stocks are available, groups may send a request for samples to tools@michaeljfox.org and may be granted access after vetting.
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AAV2/5-CBh-Alpha-Synuclein
Viral Vector (AAV2/5 serotype) encoding wild-type human alpha-synuclein. AAV2/5-CBh-empty vector control is available as a control (listed in the Other gene/protein type section) and the AAV-CBh-alpha-synuclein plasmid is available in the Plasmid section.
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HdAd5 3xFLAG-TK
Helper-dependent Adenovirus 5 viral vector with human synapsin promoter driving the expression of 3XFLAG-tagged TK. For use as a control with the HdAd5 3xFLAG-LRRK2 (WT, G2019S, G2385R) viral vectors.
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AAV1/2-CAG-Human SNCA 3xmiR/GFP
CNS optimized viral vector (AAV1/2 pseudotype) encoding GFP and 3XmiR to alpha-synuclein for specific knockdown of WT human a-syn and common pathogenic mutant forms (A53T, A30P, E46K). Scrambled Control 3xSCRmiR/GFP available as a control in Reporter section and AAV Human SNCA 3xmiR/GFP plasmid available in the Plasmid section.
Generated as part of the Industry Tools Consortium.
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AAV1/2-CAG-Mouse SNCA 3xmiR/GFP
CNS optimized viral vector (AAV1/2 pseudotype) encoding GFP and 3XmiR to alpha-synuclein for specific knockdown of WT mouse a-syn and common pathogenic mutant forms (A53T, A30P, E46K). Scrambled Control 3xSCRmiR/GFP available as a control in Reporter section and AAV Mouse SNCA 3xmiR/GFP plasmid available in the Plasmid section.
Generated as part of the Industry Tools Consortium.
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.