To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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Cell line stably expressing mutant LRRK2 G2019S (KI) (Type: Raw 264.7 macrophages)
RAW 264.7 macrophage cell line expressing a G2019S mutation in LRRK2 knocked into the endogenous mouse LRRK2 protein using zinc-finger nuclease (ZFN)-assisted adeno viral vector (AAV) technology to generate a stable cell line.
We were unable to generate this cell line due to technical difficulty and have discontinued production.
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Cell line stably expressing mutant LRRK2 T1348N (KI) (Type: Raw 264.7 macrophages)
RAW 264.7 macrophage cell line expressing a T1348N mutation in LRRK2 knocked into the endogenous mouse LRRK2 protein using zinc-finger nuclease (ZFN)-assisted adeno viral vector (AAV) technology to generate a stable cell line.
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Lentiviral eGFP
Lentiviral vector encoding eGFP
Please note: This viral vector is not intended for in vivo use.
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TH-GFP Rat (non-X-linked)
Rats expressing green fluorescent protein (GFP) under the rat tyrosine hydroxylase (TH) promotor. This is a non-X-linked mutation.
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LRRK2 Full-Length Protein (Human)
Full-Length human LRRK2 protein generated in vitro and assessed for kinase activity.
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Parkin Plasmids
DNA Plasmids encoding various Parkin cDNA inserts
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PINK1 Plasmids
DNA Plasmids encoding various PINK1 cDNA inserts
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VPS35 Plasmids
DNA Plasmids encoding various VPS35 cDNA inserts
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic