To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
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AAK1 pS623 Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against Serine 623 of AAK1.
Estimated Availability: Late 2025
AAV Human SNCA 3xmiR/GFP Plasmid
DNA Plasmids
Viral transgene plasmid used in the AAV Human SNCA 3xmiR/GFP viral vector available through Charles River Labs (see viral vector section). This plasmid is available to non-profit groups only. RRID:Addgene_194247
AAV Mouse SNCA 3xmiR/GFP Plasmid
DNA Plasmids
Viral transgene plasmid used in the AAV Mouse SNCA 3xmiR/GFP viral vector available through Charles River Labs (see viral vector section). This plasmid is available to non-profit groups only. RRID:Addgene_194248
AAV Scrambled Control 3xmiR/GFP Plasmid
DNA Plasmids
Viral transgene plasmid used in the AAV scrambled control 3xmiR/GFP viral vector available through Charles River Labs (see viral vector section). This plasmid is available to non-profit groups only. RRID:Addgene_194249
AAV1/2 A53T Alpha-Synuclein Plasmid
DNA Plasmids
Viral transgene plasmid used in the AAV1/2 A53T alpha-synuclein viral vector available through Charles River Labs (see viral vector section). This plasmid is available to non-profit and for-profit groups. RRID:Addgene_194242
AAV1/2 empty vector control
DNA Plasmids
Viral transgene plasmid used in the AAV empty vector control viral vector for the AAV A53T alpha-synuclein viral vector, both available through Charles River Labs (see viral vector section). This plasmid is available to non-profit and for-profit groups. RRID:Addgene_194243
AAV1/2-CAG-A53T Alpha-Synuclein
Viral Vector
Viral Vector (AAV1/2 serotype) encoding alpha-synuclein with the A53T mutation. AAV1/2 empty vector available as a control in Reporter section and the AAV-CAG-A53T alpha-synuclein plasmid is available in the Plasmid section.
AAV1/2-CAG-empty vector
Viral Vector
Viral Vector (AAV1/2 serotype) to serve as a control vector for the AAV1/2-CAG-A53T aSyn viral vector. The AAV-CAG-empty vector plasmid is also available in the Plasmid section.
AAV1/2-CAG-Human SNCA 3xmiR/GFP
Viral Vector
CNS optimized viral vector (AAV1/2 pseudotype) encoding GFP and 3XmiR to alpha-synuclein for specific knockdown of WT human a-syn and common pathogenic mutant forms (A53T, A30P, E46K). Scrambled Control 3xSCRmiR/GFP available as a control in Reporter section and AAV Human SNCA 3xmiR/GFP plasmid available in the Plasmid section.
Generated as part of the Industry Tools Consortium.
AAV1/2-CAG-Mouse SNCA 3xmiR/GFP
Viral Vector
CNS optimized viral vector (AAV1/2 pseudotype) encoding GFP and 3XmiR to alpha-synuclein for specific knockdown of WT mouse a-syn and common pathogenic mutant forms (A53T, A30P, E46K). Scrambled Control 3xSCRmiR/GFP available as a control in Reporter section and AAV Mouse SNCA 3xmiR/GFP plasmid available in the Plasmid section.
Generated as part of the Industry Tools Consortium.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic