Amy L. Wilson-Delfosse graduated with honors from The College of Wooster with a BA in Chemistry. She received her PhD from the Department of Pharmacology at Vanderbilt University where she was a member of the laboratory of Dr. Lee Limbird. She went on to postdoctoral training with Dr. William Maltese at the Weis Center for Research at the Geisinger Clinic in Danville, Pennsylvania, where she developed her interests in Ras-related GTPases. 

At Case Western Reserve University School of Medicine she initially focused on the characterization of Rho family GTPase protein-protein interactions that regulate GTPase localization and activity. More recently, she has dedicated her research efforts to the study of Leucine Rich Repeat Kinase 2 (LRRK2) and specifically how the GTPase domain of LRRK2 contributes to the pathogenesis of Parkinson’s disease.