Brent Ryan, BSc, PhD, is a biochemist with a primary interest in the intersection between mitochondrial dysfunction and the genetics of Parkinson’s disease (PD). The Ryan lab uses high-throughput biology approaches to understand neurodegenerative diseases such as PD using cellular models and is particularly interested in the role of mitochondrial dysfunction and mitophagy in the loss of dopamine neurons. To accomplish this, he integrates high-content imaging, proteomics and screening-based approaches and applies these to cellular models of PD. Dr. Ryan has contributed to a number of studies identifying mitochondrial and lysosomal dysfunction in SNCA, GBA, LRRK2 and PRKN cellular models, identifying and validating several novel therapeutic candidates. https://www.dpag.ox.ac.uk/research/ryan-group