Dr. Sanacora is George D. Gross and Esther S. Gross Professor of Psychiatry at Yale University, director of the Yale Depression Research Program and co-director of the Yale-New Haven Hospital Interventional Psychiatry Service. Dr. Sanacora’s career has focused on elucidating the pathophysiological mechanisms associated with mood and other neuropsychiatric disorders and using this information to inform the development of novel treatment strategies. His preclinical research explores the effects of stress and pharmaceutical agents on cellular biology, neurophysiology and behavior. His clinical laboratory employs novel imaging methodologies to investigate the pathophysiology of neuropsychiatric disorders and the mechanisms of action underlying neuropsychiatric treatments. He has served as principal investigator on several large clinical trials investigating the efficacy and safety of newly developed therapeutic agents.

Most notably, he led a series of studies examining the efficacy of ketamine and has helped to provide direction for its use in clinical settings.