After initial training in mathematics/physics and an engineering degree from the Ecole Polytechnique (France), Herve Rhinn, PhD, obtained a PhD in molecular biology at Pierre and Marie University (Paris, France), during which he developed gene expression measurement methodologies and studied transcriptional alterations in pre-clinical models of cerebral ischemia and traumatic brain injury. As a postdoctoral scientist in Dr. Asa Abeliovich's lab at Columbia University (New York), he worked on neurodegenerative diseases, with a specific focus on the genetics and pathogenesis processes of Parkinson's and Alzheimer's diseases. Dr. Rhinn developed gene expression network tools and applied them to the study of the sporadic forms of those diseases, highlighting a pathogenic role for alpha-synuclein transcripts with extended three prime untranslated region in Parkinson's disease and identifying molecular effector of APOE in Alzheimer's disease.
Associated Grants
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Alpha-synuclein Three Prime Untranslated Region (3’UTR) Modulation in Parkinson's Disease
2013