Dr. Steyaert obtained his PhD from the protein-engineering department at Plant Genetic Systems (currently Bayer Crop science). After completing post-doctoral training at the International Livestock Research Institute in Nairobi, Kenya, he joined the laboratory of structural biology of Dr. Lode Wyns.
He is co-founder of Ablynx and Agrosafve and founder and senior advisor of Confo Therapeutics, three biotech spin-offs that are studying a unique family of single-domain antibodies (immune system cells), or nanobodies.
Last year, the Steyaert lab pioneered the use of nanobodies for chaperone-assisted X-ray crystallography (technique to determine crystal structure) to study membrane proteins, amyloidogenic proteins (cause protein clumping), and (transient) multi-protein complexes. Recent work has focused on exploiting the structural complexity of therapeutic targets for nanobody-enabled drug discovery.
Associated Grants
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Development of Nanobodies as Novel Tools to Characterize LRRK2 as a Potential Drug Target for Parkinson's Disease
2017