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Kirsten Harvey, MD, PhD

Dr. at The School of Pharmacy

Location: London United Kingdom

Dr. Harvey is a reader in molecular neuroscience and cell biology at the School of Pharmacy, University of London. In 2003, she started studying kinases and interactors involved in Parkinson’s disease, looking at the mitochondrial kinase PINK1. Since 2005, she has focused her research on protein interactors of the PARK8-encoded protein LRRK2 with the aim to further research into the role of LRRK2 in processes leading to neurodegeneration. This work was initially supported by grants from the British Medical Association and the Royal Society. This allowed her to a) contribute to work suggesting that the modification of LRRK2 GTPase and kinase activity by familial PD mutations leads to neuronal cell death and b) to characterize an interaction between dishevelled family proteins and LRRK2 linking LRRK2 to Wnt signalling pathways. The continued characterization of LRRK2-dishevelled interactions is currently supported by grants from the Wellcome Trust and the Michael J Fox Foundation.


Associated Grants

  • New Roles for the Parkinson's Disease Kinase LRRK2 in Cytoskeletal Dynamics

    2011


  • The Role of LRRK2 in Wnt Signaling In Vivo

    2010


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