Dr. Marc G. Caron is a James B. Duke Professor in Cell Biology at Duke University. His laboratory has worked in two main areas: around the largest class of receptors in the genome, the G protein-coupled receptors (GPCR), and in the family of neurotransmitter transporters. Over the years, the lab has engineered and characterized a large number of genetically modified models to understand underpinnings of various brain disorders. His laboratory was one of the first to demonstrate the idea that distinct signaling functions of GPCRs, like in dopamine receptors, have important physiological consequences. Recently, his laboratory has provided evidence that limiting the canonical G-protein signaling at the dopamine D1 receptors can eliminate levodopa-induced dyskinesias. His proposed work is to develop a small-molecule therapy to achieve this desirable result in humans.