Dr. Pedro Cabrales uses his engineering training and interest in human physiology to develop a unique approach to dealing with problems in the biomedical engineering field. He is a professor of bioengineering at the University of California, San Diego Jacobs School of Engineering and the editor-in-chief for the Microvascular Research Journal. His approach involves integrative multiscale studies that build understanding from the microscopic to the entire organism. Dr. Cabrales has developed methods for characterizing cerebral blood flow, neurological function and biochemical changes in health and disease. These techniques use engineering principles to study physiological processes in a mechanistic and quantitative way. His project brings together a multidisciplinary team with the expertise to fully evaluate how itaconate treatment regulates metabolism and inflammation in Parkinson's disease.