Peter Vangheluwe is a professor at KU Leuven in Belgium and since 2012 has led the Laboratory of Cellular Transport Systems. His research focuses on lysosomal transport systems that are implicated in Parkinson’s disease (PD) in an effort to understand the role of lysosomal dysfunction in PD. He established that ATP13A2 (PARK9) works as a lysosomal polyamine transporter and that ATP10B operates as a lysosomal glucosylceramide exporter. These breakthroughs provide new insights into the molecular mechanisms of PD, and are fueling a drug-discovery pipeline for lysosomal transport modulators. He has published more than 75 peer-reviewed publications and received two awards by the Queen Elisabeth Foundation for Neurosciences. His lab website is www.labcelltransport.com.
Associated Grants
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Establishing a Cohort of Carriers with ATP13A2 Mutations for Clinical and Biomarker Analysis
2024
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IMPACT-PD: Implications of Polyamine and Glucosylceramide Transport in Parkinson’s Disease
2024
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Identification and Characterization of Small Molecule Activators of ATP13A2 for Parkinson’s Disease Therapy
2020