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Robert Edward Drolet, PhD

Principal Scientist at Merck

Location: West Point, PA United States

Dr. Robert Drolet obtained his PhD in neuroscience from Michigan State University, where he identified compensatory mechanisms and a role for alpha-synuclein in dopamine-producing neurons in the pathogenesis of Parkinson’s disease (PD). He completed postdoctoral training in neuroscience at the Pittsburgh Institute for Neurological Disorders and is currently a principal scientist in the neuroscience department at Merck Research Laboratories. In his ten years at Merck, he has led a preclinical drug discovery programs in PD and other neurodegenerative disorders, shepherding compounds through various phases of the pipeline. His research focuses primarily on imaging-based biomarkers in neurodegenerative disease and cellular mechanisms responsible for clearing toxic protein aggregations. Ongoing research in his lab seeks to identify ways to monitor alpha-synuclein as a biomarker for PD progression, and to develop methods to inhibit its accumulation as a therapeutic approach for PD.


Associated Grants

  • Esya PD360: A Multi-parametric Platform for Establishing a Novel Lysosome-based Biomarker and Identifying Therapeutic Interventions for Parkinson’s Disease

    2022


  • Alpha-Synuclein PET Tracer Discovery

    2020


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