Dr. Sealfon is the Sara B. and Seth M. Glickenhaus Chair Professor and Chairman of the Department of Neurology at the Mount Sinai School of Medicine and Professor of Neurobiology, Pharmacology and Systems Therapeutics. His laboratory applies diverse systems biology approaches to achieve a better understanding of how drugs work and how cells recognize and generate responses to extracellular signals. His research focuses on studying signaling systems, which are critical for understanding cell responses related to Parkinson's disease, drug abuse, viral infection, and neuroendocrine reproductive function and integrates both experimental and computational approaches. Dr. Sealfon leads the multi-institutional Program for Research on Immune Modeling and Experimentation (PRIME), an NIH-supported Modeling Immunity for Biodefense Center. 

Dr. Sealfon received his AB at Princeton University. After earning his medical degree from Columbia University, Dr. Sealfon completed a medical internship and neurology residency at Massachusetts General Hospital. He first joined Mount Sinai as a fellow in neuroscience in 1986.