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  • Discovery, Synthesis, and Structure–Activity Relationship Development of a Series of N-4-(2,5-Dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4) with Oral Efficacy in an Antiparkinsonian Animal Model
    2011
    OPEN
    Title: Discovery, Synthesis, and Structure–Activity Relationship Development of a Series of N-4-(2,5-Dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4) with Oral Efficacy in an Antiparkinsonian Animal Model
    Author(s): Carrie K. Jones, Darren W. Engers, Analisa D. Thompson, Julie R. Field, Anna L. Blobaum, Stacey R. Lindsley, Ya Zhou, Rocco D. Gogliotti, Satyawan Jadhav, Rocio Zamorano, James W. Bogenpohl, Yoland Smith, Ryan D. Morrison, J. Scott Daniels, C. David Weaver, P. Jeffrey Conn, Craig W. Lindsley, Colleen M. Niswender, Corey R. Hopkins
    Journal Name: Journal of Medicinal Chemistry
    Publisher: American Chemical Society (ACS)
    Vol: 54
    Issue #: 21
    Start Page: 7639
    End Page: 7647
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1021/jm200956q
    Best OA location URL: https://europepmc.org/articles/pmc3226828?pdf=render
    Citation Count: 59
  • α6β2* and α4β2* Nicotinic Acetylcholine Receptors As Drug Targets for Parkinson's Disease
    2011
    RESTRICTED
    Title: α6β2* and α4β2* Nicotinic Acetylcholine Receptors As Drug Targets for Parkinson's Disease
    Author(s): Maryka Quik, Susan Wonnacott
    Journal Name: Pharmacological Reviews
    Publisher: American Society for Pharmacology & Experimental Therapeutics (ASPET)
    Vol: 63
    Issue #: 4
    Start Page: 938
    End Page: 966
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License:
    DOI - Digital Object Identifier: 10.1124/pr.110.003269
    Best OA location URL: https://europepmc.org/articles/pmc3186078?pdf=render
    Citation Count: 171
  • Cell Therapeutics in Parkinson's Disease
    2011
    RESTRICTED
    Title: Cell Therapeutics in Parkinson's Disease
    Author(s): Olle Lindvall, Anders Björklund
    Journal Name: Neurotherapeutics
    Publisher: Elsevier BV
    Vol: 8
    Issue #: 4
    Start Page: 539
    End Page: 548
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License: publisher-specific-oa
    DOI - Digital Object Identifier: 10.1007/s13311-011-0069-6
    Best OA location URL: https://link.springer.com/content/pdf/10.1007/s13311-011-0069-6.pdf
    Citation Count: 78
  • Plasticity in Early Alzheimer Disease
    2011
    OPEN
    Title: Plasticity in Early Alzheimer Disease
    Author(s): Nikki L. Hill, Ann Kolanowski, David Gill
    Journal Name: Topics in Geriatric Rehabilitation
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Vol: 27
    Issue #: 4
    Start Page: 257
    End Page: 267
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1097/tgr.0b013e31821e588e
    Best OA location URL: https://europepmc.org/articles/pmc3419487?pdf=render
    Citation Count: 36
  • Regulation of myocyte enhancer factor-2 transcription factors by neurotoxins
    2011
    RESTRICTED
    Title: Regulation of myocyte enhancer factor-2 transcription factors by neurotoxins
    Author(s): Hua She, Zixu Mao
    Journal Name: NeuroToxicology
    Publisher: Elsevier BV
    Vol: 32
    Issue #: 5
    Start Page: 563
    End Page: 566
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License:
    DOI - Digital Object Identifier: 10.1016/j.neuro.2011.05.019
    Best OA location URL: https://europepmc.org/articles/pmc3200477?pdf=render
    Citation Count: 15
  • Role of α6 nicotinic receptors in CNS dopaminergic function: relevance to addiction and neurological disorders
    2011
    RESTRICTED
    Title: Role of α6 nicotinic receptors in CNS dopaminergic function: relevance to addiction and neurological disorders
    Author(s): Maryka Quik, Xiomara A. Perez, Sharon R. Grady
    Journal Name: Biochemical Pharmacology
    Publisher: Elsevier BV
    Vol: 82
    Issue #: 8
    Start Page: 873
    End Page: 882
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License:
    DOI - Digital Object Identifier: 10.1016/j.bcp.2011.06.001
    Best OA location URL: https://europepmc.org/articles/pmc3264546?pdf=render
    Citation Count: 78
  • Apathy and Depression: Separate Factors in Parkinson's Disease
    2011
    OPEN
    Title: Apathy and Depression: Separate Factors in Parkinson's Disease
    Author(s): Lindsey Kirsch‐Darrow, Michael Marsiske, Michael S. Okun, Russell M. Bauer, Dawn Bowers
    Journal Name: Journal of the International Neuropsychological Society
    Publisher: Cambridge University Press (CUP)
    Vol: 17
    Issue #: 6
    Start Page: 1058
    End Page: 1066
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1017/s1355617711001068
    Best OA location URL: https://europepmc.org/articles/pmc3302577?pdf=render
    Citation Count: 130
  • Subthalamic nucleus stimulation reverses mediofrontal influence over decision threshold
    2011
    OPEN
    Title: Subthalamic nucleus stimulation reverses mediofrontal influence over decision threshold
    Author(s): James F. Cavanagh, Thomas V. Wiecki, Michael X Cohen, Christina M. Figueroa, Johan Samanta, Scott J. Sherman, Michael J. Frank
    Journal Name: Nature Neuroscience
    Publisher: Springer Science and Business Media LLC
    Vol: 14
    Issue #: 11
    Start Page: 1462
    End Page: 1467
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1038/nn.2925
    Best OA location URL: https://europepmc.org/articles/pmc3394226?pdf=render
    Citation Count: 646
  • Association of SNCA with Parkinson: Replication in the Harvard NeuroDiscovery Center Biomarker Study
    2011
    OPEN
    Title: Association of SNCA with Parkinson: Replication in the Harvard NeuroDiscovery Center Biomarker Study
    Author(s): Hongliu Ding, Alison K. Sarokhan, Sarah S. Roderick, Rachit Bakshi, Nancy E. Maher, Paymon Ashourian, Caroline G. Kan, Sunny Chun Chang, Andrea Santarlasci, Kyleen Swords, Bernard Ravina, Michael T. Hayes, U. Shivraj Sohur, Anne‐Marie Wills, Alice W. Flaherty, Vivek K. Unni, Albert Y. Hung, Dennis J. Selkoe, Michael A. Schwarzschild, Michael G. Schlossmacher, Lewis Sudarsky, John H. Growdon, Adrian J. Ivinson, Bradley T. Hyman, Clemens R. Scherzer
    Journal Name: Movement Disorders
    Publisher: Wiley
    Vol: 26
    Issue #: 12
    Start Page: 2283
    End Page: 2286
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1002/mds.23934
    Best OA location URL: https://europepmc.org/articles/pmc3337217?pdf=render
    Citation Count: 23
  • BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response
    2011
    OPEN
    Title: BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response
    Author(s): Karen Castillo, Diego Rojas‐Rivera, Fernanda Lisbona, Benjamı́n Caballero, Melissa Nassif, Felipe A. Court, Sebastian Schuck, Consuelo Ibar, Peter Walter, Jimena Sierralta, Álvaro Glavic, Claudio Hetz
    Journal Name: The EMBO Journal
    Publisher: Springer Science and Business Media LLC
    Vol: 30
    Issue #: 21
    Start Page: 4465
    End Page: 4478
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1038/emboj.2011.318
    Best OA location URL: https://europepmc.org/articles/pmc3230375?pdf=render
    Citation Count: 112
  • GFAP mutations, age at onset, and clinical subtypes in Alexander disease
    2011
    OPEN
    Title: GFAP mutations, age at onset, and clinical subtypes in Alexander disease
    Author(s): Morgan J. Prust, Jiaxian Wang, Hiroki Morizono, Albee Messing, Michael Brenner, Edgar Gordon, T. Hartka, Alexander Sokohl, Raphael Schiffmann, Heather Gordish‐Dressman, Roger L. Albin, Hernán Amartino, Kathrin Brockman, Argirios Dinopoulos, Maria Teresa Dotti, Daniel Fain, Ricardo Suárez Fernández, J Ferreira, Jon L. Fleming, Deepak Gill, Martin Griebel, Heidi A. Heilstedt, P A Kaplan, D. Lewis, M. Nakagawa, R.C. Pedersen, Alyssa Reddy, Yukio Sawaishi, Martina Schneider, Elliott H. Sherr, Yoshihisa Takiyama, K Wakabayashi, J. R. Gorospe, Adeline Vanderver
    Journal Name: Neurology
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Vol: 77
    Issue #: 13
    Start Page: 1287
    End Page: 1294
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1212/wnl.0b013e3182309f72
    Best OA location URL: https://europepmc.org/articles/pmc3179649?pdf=render
    Citation Count: 220
  • Impaired Economy of Gait and Decreased Six-Minute Walk Distance in Parkinson's Disease
    2011
    OPEN
    Title: Impaired Economy of Gait and Decreased Six-Minute Walk Distance in Parkinson's Disease
    Author(s): Leslie I. Katzel, Frederick M. Ivey, John D. Sorkin, Richard F. Macko, Barbara A. Smith, Lisa M. Shulman
    Journal Name: Parkinson's Disease
    Publisher: Wiley
    Vol: 2012
    Issue #:
    Start Page: 1
    End Page: 6
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1155/2012/241754
    Best OA location URL: https://downloads.hindawi.com/journals/pd/2012/241754.pdf
    Citation Count: 36
  • Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress
    2011
    OPEN
    Title: Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress
    Author(s): Lonnie Schneider, Samantha Giordano, Blake R. Zelickson, Michelle S. Johnson, Gloria A. Benavides, Xiaosen Ouyang, Naomi Fineberg, Victor Darley‐Usmar, Jianhua Zhang
    Journal Name: Free Radical Biology and Medicine
    Publisher: Elsevier BV
    Vol: 51
    Issue #: 11
    Start Page: 2007
    End Page: 2017
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1016/j.freeradbiomed.2011.08.030
    Best OA location URL: https://europepmc.org/articles/pmc3208787?pdf=render
    Citation Count: 189
  • Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case–control study
    2011
    OPEN
    Title: Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case–control study
    Author(s): Owen A. Ross, Alexandra I. Soto‐Ortolaza, Michael G. Heckman, Jan Aasly, Nadine Abahuni, Grazia Annesi, Justin A. Bacon, Soraya Bardien, Maria Bozi, Alexis Brice, Laura Brighina, Christine Van Broeckhoven, Jonathan Carr, Marie‐Christine Chartier‐Harlin, Efthimios Dardiotis, Dennis W. Dickson, Nancy N. Diehl, Alexis Elbaz, Carlo Ferrarese, Alessandro Ferraris, Brian Fiske, J. Mark Gibson, Rachel A. Gibson, Georgios M. Hadjigeorgiou, Nobutaka Hattori, John P. A. Ioannidis, Barbara Jasińska‐Myga, Beom S. Jeon, Yun Joong Kim, Christine Klein, Rejko Krüger, Elli Kyratzi, Suzanne Lesage, Chin‐Hsien Lin, Timothy Lynch, Demetrius M. Maraganore, George D. Mellick, Eugénie Mutez, Christer Nilsson, Grzegorz Opala, Sung Sup Park, Andreas Puschmann, Aldo Quattrone, Manu Sharma, Peter A. Silburn, Young H. Sohn, Leonidas Stefanis, Vera Tadić, Jessie Theuns, Hiroyuki Tomiyama, Ryan J. Uitti, Enza Maria Valente, Simone van de Loo, Demetrios K. Vassilatis, Carles Vilariño‐Güell, Linda R. White, Karin Wirdefeldt, Zbigniew K. Wszołek, Ruey‐Meei Wu, Matthew J. Farrer
    Journal Name: The Lancet Neurology
    Publisher: Elsevier BV
    Vol: 10
    Issue #: 10
    Start Page: 898
    End Page: 908
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1016/s1474-4422(11)70175-2
    Best OA location URL: https://research-repository.griffith.edu.au/bitstream/10072/43372/1/MellickPUB8.pdf
    Citation Count: 312
  • Drug Targets from Genetics: Alpha-Synuclein
    2011
    RESTRICTED
    Title: Drug Targets from Genetics: Alpha-Synuclein
    Author(s): Karin M. Danzer, Pamela J. McLean
    Journal Name: CNS & Neurological Disorders - Drug Targets
    Publisher: Bentham Science Publishers Ltd.
    Vol: 10
    Issue #: 6
    Start Page: 712
    End Page: 723
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License:
    DOI - Digital Object Identifier: 10.2174/187152711797247867
    Best OA location URL: https://europepmc.org/articles/pmc3364517?pdf=render
    Citation Count: 10
  • Familial Aggregation of Panic Disturbances in Parkinson's Disease
    2011
    OPEN
    Title: Familial Aggregation of Panic Disturbances in Parkinson's Disease
    Author(s): Gregory M. Pontone, Justin Palanci, O. Joseph Bienvenu, Kung‐Yee Liang, Gerald Nestadt, Peter V. Rabins, James R. Williams, Laura Marsh
    Journal Name: Journal of Neuropsychiatry
    Publisher: American Psychiatric Association Publishing
    Vol: 23
    Issue #: 4
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1176/appi.neuropsych.23.4.417
    Best OA location URL: https://europepmc.org/articles/pmc3547673?pdf=render
    Citation Count: 1
  • Translation Initiator EIF4G1 Mutations in Familial Parkinson Disease
    2011
    OPEN
    Title: Translation Initiator EIF4G1 Mutations in Familial Parkinson Disease
    Author(s): Marie‐Christine Chartier‐Harlin, Justus C. Dächsel, Carles Vilariño‐Güell, Sarah Lincoln, Frédéric Leprêtre, Mary Hulihan, Jennifer M. Kachergus, Austen J. Milnerwood, Lucı́a Tapia, Mee-Sook Song, Émilie Le Rhun, Eugénie Mutez, Lydie Larvor, Aurélie Duflot, Christel Vanbesien-Mailliot, Alexandre Kreisler, Owen A. Ross, Kenya Nishioka, Alexandra I. Soto‐Ortolaza, Stephanie A. Cobb, Heather L. Melrose, Bahareh Behrouz, Brett H. Keeling, Justin A. Bacon, Emna Hentati, Lindsey N. Williams, Akiko Yanagiya, Nahum Sonenberg, Paul J. Lockhart, Abba C. Zubair, Ryan J. Uitti, Jan Aasly, Anna Krygowska‐Wajs, Grzegorz Opala, Zbigniew K. Wszołek, Roberta Frigerio, Demetrius M. Maraganore, David Gosal, Tim Lynch, Michael Hutchinson, Anna Rita Bentivoglio, Enza Maria Valente, William C. Nichols, Nathan Pankratz, Tatiana Foroud, Rachel A. Gibson, Fayçal Hentati, Dennis W. Dickson, A. Destée, Matthew J. Farrer
    Journal Name: The American Journal of Human Genetics
    Publisher: Elsevier BV
    Vol: 89
    Issue #: 3
    Start Page: 398
    End Page: 406
    Publication Date:
    Open Access(OA) Status: OPEN
    License: publisher-specific-oa
    DOI - Digital Object Identifier: 10.1016/j.ajhg.2011.08.009
    Best OA location URL: http://www.cell.com/article/S0002929711003594/pdf
    Citation Count: 277
  • A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson's disease
    2011
    RESTRICTED
    Title: A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson's disease
    Author(s): Hélène Pouclet, Thibaud Lebouvier, Emmanuel Coron, Stanislas Bruley des Varannes, Tiphaine Rouaud, Monica Roy, Michel Neunlist, Pascal Derkinderen
    Journal Name: Neurobiology of Disease
    Publisher: Elsevier BV
    Vol: 45
    Issue #: 1
    Start Page: 305
    End Page: 309
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License:
    DOI - Digital Object Identifier: 10.1016/j.nbd.2011.08.014
    Best OA location URL:
    Citation Count: 130
  • Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
    2011
    OPEN
    Title: Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
    Author(s): Michael J. Devine, Mina Ryten, Petr Vodička, Alison J. Thomson, Tom Burdon, Henry Houlden, Fatima Cavaleri, Masumi Nagano, Nicola J. Drummond, Jan‐Willem Taanman, Anthony H.V. Schapira, Katrina Gwinn, John Hardy, Patrick A. Lewis, Tilo Kunath
    Journal Name: Nature Communications
    Publisher: Springer Science and Business Media LLC
    Vol: 2
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-sa
    DOI - Digital Object Identifier: 10.1038/ncomms1453
    Best OA location URL: https://www.nature.com/articles/ncomms1453.pdf
    Citation Count: 438
  • Network correlates of the cognitive response to levodopa in Parkinson disease
    2011
    OPEN
    Title: Network correlates of the cognitive response to levodopa in Parkinson disease
    Author(s): Paul J. Mattis, Chengke Tang, Yilong Ma, Vijay Dhawan, David Eidelberg
    Journal Name: Neurology
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Vol: 77
    Issue #: 9
    Start Page: 858
    End Page: 865
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1212/wnl.0b013e31822c6224
    Best OA location URL: https://europepmc.org/articles/pmc3162641?pdf=render
    Citation Count: 63
  • Regional alterations of brain microstructure in Parkinson's disease using diffusion tensor imaging
    2011
    OPEN
    Title: Regional alterations of brain microstructure in Parkinson's disease using diffusion tensor imaging
    Author(s): Wang Zhan, Gail A. Kang, Graham A. Glass, Yu Zhang, Cheryl Shirley, Rachel Millin, Katherine L. Possin, Marzieh Nezamzadeh, Michael W. Weiner, William J. Marks, Norbert Schuff
    Journal Name: Movement Disorders
    Publisher: Wiley
    Vol: 27
    Issue #: 1
    Start Page: 90
    End Page: 97
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1002/mds.23917
    Best OA location URL: https://europepmc.org/articles/pmc4472452?pdf=render
    Citation Count: 173
  • Neurologist care in Parkinson disease
    2011
    OPEN
    Title: Neurologist care in Parkinson disease
    Author(s): Allison W. Willis, Mario Schootman, Bradley Evanoff, Joel S. Perlmutter, Brad A. Racette
    Journal Name: Neurology
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Vol: 77
    Issue #: 9
    Start Page: 851
    End Page: 857
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1212/wnl.0b013e31822c9123
    Best OA location URL: https://europepmc.org/articles/pmc3162639?pdf=render
    Citation Count: 255
  • Induction of pluripotent stem cells from autopsy donor-derived somatic cells
    2011
    OPEN
    Title: Induction of pluripotent stem cells from autopsy donor-derived somatic cells
    Author(s): Brooke E. Hjelm, Jon B. Rosenberg, Szabolcs Szelinger, Lucia I. Sue, Thomas G. Beach, Matthew J. Huentelman, David W. Craig
    Journal Name: Neuroscience Letters
    Publisher: Elsevier BV
    Vol: 502
    Issue #: 3
    Start Page: 219
    End Page: 224
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1016/j.neulet.2011.07.048
    Best OA location URL: https://europepmc.org/articles/pmc3195418?pdf=render
    Citation Count: 25
  • Transgene expression in the striatum following intracerebral injections of DNA nanoparticles encoding for human glial cell line-derived neurotrophic factor
    2011
    OPEN
    Title: Transgene expression in the striatum following intracerebral injections of DNA nanoparticles encoding for human glial cell line-derived neurotrophic factor
    Author(s): Anita Fletcher, T. Kowalczyk, Linas Padegimas, Mark J. Cooper, David M. Yurek
    Journal Name: Neuroscience
    Publisher: Elsevier BV
    Vol: 194
    Issue #:
    Start Page: 220
    End Page: 226
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1016/j.neuroscience.2011.07.072
    Best OA location URL: https://europepmc.org/articles/pmc3408714?pdf=render
    Citation Count: 34
  • Cdk5: Mediator of neuronal development, death and the response to DNA damage
    2011
    RESTRICTED
    Title: Cdk5: Mediator of neuronal development, death and the response to DNA damage
    Author(s): Jingru Zhu, Wenming Li, Zixu Mao
    Journal Name: Mechanisms of Ageing and Development
    Publisher: Elsevier BV
    Vol: 132
    Issue #: 8-9
    Start Page: 389
    End Page: 394
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License:
    DOI - Digital Object Identifier: 10.1016/j.mad.2011.04.011
    Best OA location URL: https://europepmc.org/articles/pmc3179526?pdf=render
    Citation Count: 25
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