5701 - 5750 of 8112 Results
Title
Year
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RESTRICTEDTitle: Gene Therapy Strategies to Restore ER Proteostasis in DiseaseJournal Name: Molecular TherapyPublisher: Elsevier BVVol: 26Issue #: 6Start Page: 1404End Page: 1413Publication Date:Open Access(OA) Status: RESTRICTEDLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.ymthe.2018.04.004Best OA location URL: https://doi.org/10.1016/j.ymthe.2018.04.004Citation Count: 35
- Longitudinal studies of botulinum toxin in cervical dystonia: Why do patients discontinue therapy?2018RESTRICTEDTitle: Longitudinal studies of botulinum toxin in cervical dystonia: Why do patients discontinue therapy?Journal Name: ToxiconPublisher: Elsevier BVVol: 147Issue #:Start Page: 89End Page: 95Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.toxicon.2017.09.004Best OA location URL: https://europepmc.org/articles/pmc5839920?pdf=renderCitation Count: 49
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OPENTitle: Mechanism of parkin activation by PINK1Journal Name: NaturePublisher: Springer Science and Business Media LLCVol: 559Issue #: 7714Start Page: 410End Page: 414Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/s41586-018-0224-xBest OA location URL: https://europepmc.org/articles/pmc6071873?pdf=renderCitation Count: 326
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RESTRICTEDTitle: mGlu4 allosteric modulation for treating Parkinson's diseaseJournal Name: NeuropharmacologyPublisher: Elsevier BVVol: 135Issue #:Start Page: 308End Page: 315Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.neuropharm.2018.03.027Citation Count: 27
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RESTRICTEDTitle: The spectrum of “off” in Parkinson's disease: What have we learned over 40 years?Journal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 51Issue #:Start Page: 9End Page: 16Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2018.02.001Citation Count: 108
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OPENTitle: Immunosuppressants and risk of Parkinson diseaseJournal Name: Annals of Clinical and Translational NeurologyPublisher: WileyVol: 5Issue #: 7Start Page: 870End Page: 875Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1002/acn3.580Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.580Citation Count: 77
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OPENTitle: LRRK2 activity does not dramatically alter α-synuclein pathology in primary neuronsJournal Name: Acta Neuropathologica CommunicationsPublisher: Springer Science and Business Media LLCVol: 6Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s40478-018-0550-0Best OA location URL: https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-018-0550-0Citation Count: 33
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OPENTitle: Partial ablation of the orexin field induces a sub-narcoleptic phenotype in a conditional mouse model of orexin neurodegenerationJournal Name: SleepPublisher: Oxford University Press (OUP)Vol: 41Issue #: 9Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/sleep/zsy116Best OA location URL: https://academic.oup.com/sleep/article-pdf/41/9/zsy116/25714846/zsy116.pdfCitation Count: 12
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RESTRICTEDTitle: Cerebral Imaging Markers of GBA and LRRK2 Related Parkinson’s Disease and Their First-Degree Unaffected RelativesJournal Name: Brain TopographyPublisher: Springer Science and Business Media LLCVol: 31Issue #: 6Start Page: 1029End Page: 1036Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1007/s10548-018-0653-8Citation Count: 26
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OPENTitle: Dopamine Transporter/α-Synuclein Complexes Are Altered in the Post Mortem Caudate Putamen of Parkinson’s Disease: An In Situ Proximity Ligation Assay StudyJournal Name: International Journal of Molecular SciencesPublisher: MDPI AGVol: 19Issue #: 6Start Page: 1611End Page: 1611Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3390/ijms19061611Best OA location URL: https://www.mdpi.com/1422-0067/19/6/1611/pdf?version=1527671383Citation Count: 22
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OPENTitle: Early Gray Matter Volume Loss in MAPT H1H1 de Novo PD Patients: A Possible Association With Cognitive DeclineJournal Name: Frontiers in NeurologyPublisher: Frontiers Media SAVol: 9Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fneur.2018.00394Best OA location URL: https://www.frontiersin.org/articles/10.3389/fneur.2018.00394/pdfCitation Count: 14
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OPENTitle: Increased yield of full GBA sequencing in Ashkenazi Jews with Parkinson's diseaseJournal Name: European Journal of Medical GeneticsPublisher: Elsevier BVVol: 62Issue #: 1Start Page: 65End Page: 69Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.ejmg.2018.05.005Best OA location URL: https://europepmc.org/articles/pmc6261782?pdf=renderCitation Count: 57
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OPENTitle: A novel extended form of alpha-synuclein 3′UTR in the human brainJournal Name: Molecular BrainPublisher: Springer Science and Business Media LLCVol: 11Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s13041-018-0371-xBest OA location URL: https://molecularbrain.biomedcentral.com/track/pdf/10.1186/s13041-018-0371-xCitation Count: 14
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OPENTitle: RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's diseaseJournal Name: Journal of Biological ChemistryPublisher: Elsevier BVVol: 293Issue #: 28Start Page: 11047End Page: 11066Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1074/jbc.ra118.001747Best OA location URL: https://europepmc.org/articles/pmc6052236?pdf=renderCitation Count: 72
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OPENTitle: Patterns and Predictors of Tic Suppressibility in Youth With Tic DisordersJournal Name: Frontiers in PsychiatryPublisher: Frontiers Media SAVol: 9Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fpsyt.2018.00188Best OA location URL: https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00188/pdfCitation Count: 44
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OPENTitle: Separation of Subcutaneous Fat From Muscle in Surface Electrical Impedance Myography Measurements Using Model Component AnalysisJournal Name: IEEE Transactions on Biomedical EngineeringPublisher: Institute of Electrical and Electronics Engineers (IEEE)Vol: 66Issue #: 2Start Page: 354End Page: 364Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1109/tbme.2018.2839977Best OA location URL: https://europepmc.org/articles/pmc6357232?pdf=renderCitation Count: 19
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RESTRICTEDTitle: Determination of Imaging Biomarkers to Decipher Disease Trajectories and Differential Diagnosis of Neurodegenerative Diseases (DIsease TreND)Journal Name: Journal of Neuroscience MethodsPublisher: Elsevier BVVol: 305Issue #:Start Page: 105End Page: 116Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.jneumeth.2018.05.009Citation Count: 18
- LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages2018OPENTitle: LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophagesJournal Name: The EMBO JournalPublisher: Springer Science and Business Media LLCVol: 37Issue #: 12Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.15252/embj.201798694Best OA location URL: https://doi.org/10.15252/embj.201798694Citation Count: 159
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OPENTitle: Intermittent convection-enhanced delivery of GDNF into rhesus monkey putamen: absence of local or cerebellar toxicityJournal Name: Archives of ToxicologyPublisher: Springer Science and Business Media LLCVol: 92Issue #: 7Start Page: 2353End Page: 2367Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1007/s00204-018-2222-zBest OA location URL: https://link.springer.com/content/pdf/10.1007/s00204-018-2222-z.pdfCitation Count: 19
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OPENTitle: Tolerogenic bone marrow-derived dendritic cells induce neuroprotective regulatory T cells in a model of Parkinson’s diseaseJournal Name: Molecular NeurodegenerationPublisher: Springer Science and Business Media LLCVol: 13Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s13024-018-0255-7Best OA location URL: https://molecularneurodegeneration.biomedcentral.com/track/pdf/10.1186/s13024-018-0255-7Citation Count: 51
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RESTRICTEDTitle: Intranasal Delivery of pGDNF DNA Nanoparticles Provides Neuroprotection in the Rat 6-Hydroxydopamine Model of Parkinson’s DiseaseJournal Name: Molecular NeurobiologyPublisher: Springer Science and Business Media LLCVol: 56Issue #: 1Start Page: 688End Page: 701Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1007/s12035-018-1109-6Citation Count: 55
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OPENTitle: Human cerebral collateral arteriole function in subjects with normal cognition, mild cognitive impairment, and dementiaJournal Name: American Journal of Physiology-Heart and Circulatory PhysiologyPublisher: American Physiological SocietyVol: 315Issue #: 2Start Page: H284End Page: H290Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1152/ajpheart.00206.2018Best OA location URL: https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00206.2018Citation Count: 11
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OPENTitle: Somatic copy number gains of α-synuclein (SNCA) in Parkinson’s disease and multiple system atrophy brainsJournal Name: BrainPublisher: Oxford University Press (OUP)Vol: 141Issue #: 8Start Page: 2419End Page: 2431Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/brain/awy157Best OA location URL: https://academic.oup.com/brain/article-pdf/141/8/2419/25219708/awy157.pdfCitation Count: 68
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RESTRICTEDTitle: Parkinson's disease phenotype is influenced by the severity of the mutations in the GBA geneJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 55Issue #:Start Page: 45End Page: 49Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2018.05.009Citation Count: 102
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OPENTitle: Predicting alpha-synuclein pathology by REM sleep behavior disorder diagnosisJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 55Issue #:Start Page: 92End Page: 96Publication Date:Open Access(OA) Status: OPENLicense: elsevier-specific: oa user licenseDOI - Digital Object Identifier: 10.1016/j.parkreldis.2018.05.020Best OA location URL: http://manuscript.elsevier.com/S1353802018302529/pdf/S1353802018302529.pdfCitation Count: 25
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OPENTitle: Tissue engineered nigrostriatal pathway for treatment of Parkinson's diseaseJournal Name: Journal of Tissue Engineering and Regenerative MedicinePublisher: WileyVol: 12Issue #: 7Start Page: 1702End Page: 1716Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/term.2698Best OA location URL: https://europepmc.org/articles/pmc6416379?pdf=renderCitation Count: 57
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OPENTitle: α‐Synuclein stimulation of monoamine oxidase‐B and legumain protease mediates the pathology of Parkinson's diseaseJournal Name: The EMBO JournalPublisher: Springer Science and Business Media LLCVol: 37Issue #: 12Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.15252/embj.201798878Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embj.201798878Citation Count: 75
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OPENTitle: Biochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic ProfilesJournal Name: Journal of Proteome ResearchPublisher: American Chemical Society (ACS)Vol: 17Issue #: 7Start Page: 2460End Page: 2469Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1021/acs.jproteome.8b00224Best OA location URL: https://europepmc.org/articles/pmc6599609?pdf=renderCitation Count: 63
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OPENTitle: Cognitive training for freezing of gait in Parkinson’s disease: a randomized controlled trialJournal Name: npj Parkinson's DiseasePublisher: Springer Science and Business Media LLCVol: 4Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41531-018-0052-6Best OA location URL: https://www.nature.com/articles/s41531-018-0052-6.pdfCitation Count: 75
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OPENTitle: Full sequencing and haplotype analysis of MAPT in Parkinson's disease and rapid eye movement sleep behavior disorderJournal Name: Movement DisordersPublisher: WileyVol: 33Issue #: 6Start Page: 1016End Page: 1020Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.27385Best OA location URL: http://hdl.handle.net/20.500.11794/33612Citation Count: 37
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OPENTitle: Inhaling xenon ameliorates l‐dopa‐induced dyskinesia in experimental parkinsonismJournal Name: Movement DisordersPublisher: WileyVol: 33Issue #: 10Start Page: 1632End Page: 1642Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1002/mds.27404Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mds.27404Citation Count: 15
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OPENTitle: Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson’s diseaseJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 115Issue #: 22Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.1718946115Best OA location URL: https://www.pnas.org/content/pnas/115/22/E5164.full.pdfCitation Count: 105
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OPENTitle: Varying the rate of intravenous cocaine infusion influences the temporal dynamics of both drug and dopamine concentrations in the striatumJournal Name: European Journal of NeurosciencePublisher: WileyVol: 50Issue #: 3Start Page: 2054End Page: 2064Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/ejn.13941Best OA location URL: http://deepblue.lib.umich.edu/bitstream/2027.42/151808/2/ejn13941.pdfCitation Count: 19
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OPENTitle: Alpha Synuclein Fibrils Contain Multiple Binding Sites for Small MoleculesJournal Name: ACS Chemical NeurosciencePublisher: American Chemical Society (ACS)Vol: 9Issue #: 11Start Page: 2521End Page: 2527Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1021/acschemneuro.8b00177Best OA location URL: https://europepmc.org/articles/pmc6736640?pdf=renderCitation Count: 60
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OPENTitle: Alterations of Brain Structural Network in Parkinson’s Disease With and Without Rapid Eye Movement Sleep Behavior DisorderJournal Name: Frontiers in NeurologyPublisher: Frontiers Media SAVol: 9Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fneur.2018.00334Best OA location URL: https://www.frontiersin.org/articles/10.3389/fneur.2018.00334/pdfCitation Count: 26
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OPENTitle: Generation of three-dimensional human neuronal cultures: application to modeling CNS viral infectionsJournal Name: Stem Cell Research & TherapyPublisher: Springer Science and Business Media LLCVol: 9Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s13287-018-0881-6Best OA location URL: https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-018-0881-6Citation Count: 40
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OPENTitle: The deterministic role of 5-mers in microRNA-gene targetingJournal Name: RNA BiologyPublisher: Informa UK LimitedVol:Issue #:Start Page: 1End Page: 7Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1080/15476286.2018.1462652Best OA location URL: https://www.tandfonline.com/doi/pdf/10.1080/15476286.2018.1462652?needAccess=trueCitation Count: 15
- Bdnf variant is associated with milder motor symptom severity in early-stage Parkinson's disease2018RESTRICTEDTitle: Bdnf variant is associated with milder motor symptom severity in early-stage Parkinson's diseaseJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 53Issue #:Start Page: 70End Page: 75Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2018.05.003Citation Count: 18
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OPENTitle: The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and humanJournal Name: Biochemical JournalPublisher: Portland Press Ltd.Vol: 475Issue #: 11Start Page: 1861End Page: 1883Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1042/bcj20180248Best OA location URL: https://portlandpress.com/biochemj/article-pdf/475/11/1861/691623/bcj-2018-0248.pdfCitation Count: 179
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OPENTitle: Circular RNA expression and regulatory network prediction in posterior cingulate astrocytes in elderly subjectsJournal Name: BMC GenomicsPublisher: Springer Science and Business Media LLCVol: 19Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s12864-018-4670-5Best OA location URL: https://bmcgenomics.biomedcentral.com/track/pdf/10.1186/s12864-018-4670-5Citation Count: 32
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OPENTitle: Computer-aided diagnosis for (123I)FP-CIT imaging: impact on clinical reportingJournal Name: EJNMMI ResearchPublisher: Springer Science and Business Media LLCVol: 8Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s13550-018-0393-5Best OA location URL: https://ejnmmires.springeropen.com/track/pdf/10.1186/s13550-018-0393-5Citation Count: 10
- Phosphorylated α‐synuclein in the retina is a biomarker of Parkinson's disease pathology severity2018OPENTitle: Phosphorylated α‐synuclein in the retina is a biomarker of Parkinson's disease pathology severityJournal Name: Movement DisordersPublisher: WileyVol: 33Issue #: 8Start Page: 1315End Page: 1324Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.27392Best OA location URL: https://europepmc.org/articles/pmc6146055?pdf=renderCitation Count: 132
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OPENTitle: Burst activation of dopamine neurons produces prolonged post-burst availability of actively released dopamineJournal Name: NeuropsychopharmacologyPublisher: Springer Science and Business Media LLCVol: 43Issue #: 10Start Page: 2083End Page: 2092Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/s41386-018-0088-7Best OA location URL: https://www.nature.com/articles/s41386-018-0088-7.pdfCitation Count: 42
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OPENTitle: Heritability estimates of cortical anatomy: The influence and reliability of different estimation strategiesJournal Name: NeuroImagePublisher: Elsevier BVVol: 178Issue #:Start Page: 78End Page: 91Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neuroimage.2018.05.014Best OA location URL: https://eprints.lancs.ac.uk/id/eprint/125120/1/1_s2.0_S1053811918304129_main.pdfCitation Count: 21
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OPENTitle: Genetic variants related to urate and risk of Parkinson's diseaseJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 53Issue #:Start Page: 4End Page: 9Publication Date:Open Access(OA) Status: OPENLicense: publisher-specific-oaDOI - Digital Object Identifier: 10.1016/j.parkreldis.2018.04.031Best OA location URL: http://manuscript.elsevier.com/S1353802018302190/pdf/S1353802018302190.pdfCitation Count: 6
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OPENTitle: Model-based and Model-free Machine Learning Techniques for Diagnostic Prediction and Classification of Clinical Outcomes in Parkinson’s DiseaseJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 8Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41598-018-24783-4Best OA location URL: https://www.nature.com/articles/s41598-018-24783-4.pdfCitation Count: 161
- α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons2018OPENTitle: α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neuronsJournal Name: Acta Neuropathologica CommunicationsPublisher: Springer Science and Business Media LLCVol: 6Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1186/s40478-018-0537-xBest OA location URL: https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-018-0537-xCitation Count: 80
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OPENTitle: Pink1 −/− Rats Show Early-Onset Swallowing Deficits and Correlative Brainstem PathologyJournal Name: DysphagiaPublisher: Springer Science and Business Media LLCVol: 33Issue #: 6Start Page: 749End Page: 758Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s00455-018-9896-5Best OA location URL: https://europepmc.org/articles/pmc6207473?pdf=renderCitation Count: 40
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OPENTitle: Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association studyJournal Name: The Lancet NeurologyPublisher: Elsevier BVVol: 17Issue #: 6Start Page: 548End Page: 558Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/s1474-4422(18)30126-1Best OA location URL: http://www.thelancet.com/article/S1474442218301261/pdfCitation Count: 109