2501 - 2550 of 7916 Results
Title
Year
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RESTRICTEDTitle: Parkinson’s Disease Videos on YouTube: Types and Characteristics of Content on Communication and CognitionJournal Name: Journal of Consumer Health on the InternetPublisher: Informa UK LimitedVol: 25Issue #: 4Start Page: 335End Page: 349Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1080/15398285.2021.1980692Citation Count: 2
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OPENTitle: Predicting Parkinson’s Disease and Its Pathology via Simple Clinical VariablesJournal Name: Journal of Parkinson's DiseasePublisher: SAGE PublicationsVol: 12Issue #: 1Start Page: 341End Page: 351Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.3233/jpd-212876Best OA location URL: https://content.iospress.com:443/download/journal-of-parkinsons-disease/jpd212876?id=journal-of-parkinsons-disease%2Fjpd212876Citation Count: 11
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OPENTitle: 146th Annual Meeting American Neurological AssociationJournal Name: Annals of NeurologyPublisher: WileyVol: 90Issue #: S27Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/ana.26180Best OA location URL: http://bura.brunel.ac.uk/bitstream/2438/24148/3/MeetingAbstract.pdfCitation Count: 14
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OPENTitle: A Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson's Disease (PASADENA): Rationale, Design, and Baseline DataJournal Name: Frontiers in NeurologyPublisher: Frontiers Media SAVol: 12Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fneur.2021.705407Best OA location URL: https://www.frontiersin.org/articles/10.3389/fneur.2021.705407/pdfCitation Count: 49
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OPENTitle: Amyloid-β, p-tau and reactive microglia are pathological correlates of MRI cortical atrophy in Alzheimer’s diseaseJournal Name: Brain CommunicationsPublisher: Oxford University Press (OUP)Vol: 3Issue #: 4Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1093/braincomms/fcab281Best OA location URL: https://academic.oup.com/braincomms/article-pdf/3/4/fcab281/41780538/fcab281.pdfCitation Count: 18
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OPENTitle: Apathy: An underestimated feature in GBA and LRRK2 non-manifesting mutation carriersJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 91Issue #:Start Page: 1End Page: 8Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2021.08.008Best OA location URL: https://www.medrxiv.org/content/medrxiv/early/2021/07/22/2021.07.20.21260819.full.pdfCitation Count: 8
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RESTRICTEDTitle: Application of the mPSPRS to the Salerno Cohort and a Comparison Between PSP‐RS and vPSPJournal Name: Movement DisordersPublisher: WileyVol: 36Issue #: 10Start Page: 2449End Page: 2451Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1002/mds.28757Citation Count: 1
- Brain atrophy progression in Parkinson’s disease is shaped by connectivity and local vulnerability2021OPENTitle: Brain atrophy progression in Parkinson’s disease is shaped by connectivity and local vulnerabilityJournal Name: Brain CommunicationsPublisher: Oxford University Press (OUP)Vol: 3Issue #: 4Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1093/braincomms/fcab269Best OA location URL: https://academic.oup.com/braincomms/article-pdf/3/4/fcab269/41729026/fcab269.pdfCitation Count: 38
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RESTRICTEDTitle: Clinical and Dopamine Transporter Imaging Trajectories in a Cohort of Parkinson's Disease Patients with GBA MutationsJournal Name: Movement DisordersPublisher: WileyVol: 37Issue #: 1Start Page: 106End Page: 118Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1002/mds.28818Citation Count: 18
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OPENTitle: ECTRIMS 2021 – ePosterJournal Name: Multiple Sclerosis JournalPublisher: SAGE PublicationsVol: 27Issue #: 2_supplStart Page: 134End Page: 740Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1177/13524585211044667Best OA location URL: https://journals.sagepub.com/doi/pdf/10.1177/13524585211044667Citation Count: 25
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OPENTitle: ECTRIMS 2021 – Late Breaking News ePosterJournal Name: Multiple Sclerosis JournalPublisher: SAGE PublicationsVol: 27Issue #: 2_supplStart Page: 752End Page: 804Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1177/13524585211047080Best OA location URL: https://journals.sagepub.com/doi/pdf/10.1177/13524585211047080Citation Count: 1
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RESTRICTEDTitle: Emerging Neuroimaging Biomarkers Across Disease Stage in Parkinson DiseaseJournal Name: JAMA NeurologyPublisher: American Medical Association (AMA)Vol: 78Issue #: 10Start Page: 1262End Page: 1262Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1001/jamaneurol.2021.1312Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017381Citation Count: 75
- Enhanced arm swing improves Parkinsonian gait with EEG power modulations resembling healthy gait2021OPENTitle: Enhanced arm swing improves Parkinsonian gait with EEG power modulations resembling healthy gaitJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 91Issue #:Start Page: 96End Page: 101Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1016/j.parkreldis.2021.09.011Best OA location URL: http://www.prd-journal.com/article/S1353802021003400/pdfCitation Count: 12
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OPENTitle: Heat Shock Protein 70 as a Sex-Skewed Regulator of α-SynucleinopathyJournal Name: NeurotherapeuticsPublisher: Elsevier BVVol: 18Issue #: 4Start Page: 2541End Page: 2564Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s13311-021-01114-6Best OA location URL: https://link.springer.com/content/pdf/10.1007/s13311-021-01114-6.pdfCitation Count: 6
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RESTRICTEDTitle: In-Home Falls Risk Assessment in Parkinson Disease: A Guide for CliniciansJournal Name: Archives of Physical Medicine and RehabilitationPublisher: Elsevier BVVol: 102Issue #: 10Start Page: 2051End Page: 2054Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.apmr.2021.04.001Citation Count: 2
- Insights into VPS13 properties and function reveal a new mechanism of eukaryotic lipid transport2021RESTRICTEDTitle: Insights into VPS13 properties and function reveal a new mechanism of eukaryotic lipid transportJournal Name: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsPublisher: Elsevier BVVol: 1866Issue #: 10Start Page: 159003End Page: 159003Publication Date:Open Access(OA) Status: RESTRICTEDLicense: cc-by, cc-by, cc-byDOI - Digital Object Identifier: 10.1016/j.bbalip.2021.159003Best OA location URL: https://doi.org/10.1016/j.bbalip.2021.159003Citation Count: 70
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RESTRICTEDTitle: Longitudinal risk factors for developing depressive symptoms in Parkinson's diseaseJournal Name: Journal of the Neurological SciencesPublisher: Elsevier BVVol: 429Issue #:Start Page: 117615End Page: 117615Publication Date:Open Access(OA) Status: RESTRICTEDLicense: publisher-specific-oaDOI - Digital Object Identifier: 10.1016/j.jns.2021.117615Best OA location URL: http://manuscript.elsevier.com/S0022510X21003099/pdf/S0022510X21003099.pdfCitation Count: 5
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RESTRICTEDTitle: Mendelian Randomization Studies: A Path to Better Understand Sex and Gender Differences in Parkinson's Disease?Journal Name: Movement DisordersPublisher: WileyVol: 36Issue #: 10Start Page: 2220End Page: 2222Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1002/mds.28765Citation Count: 4
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OPENTitle: MicroRNA-7 Protects Against Neurodegeneration Induced by α-Synuclein Preformed Fibrils in the Mouse BrainJournal Name: NeurotherapeuticsPublisher: Elsevier BVVol: 18Issue #: 4Start Page: 2529End Page: 2540Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s13311-021-01130-6Best OA location URL: https://link.springer.com/content/pdf/10.1007/s13311-021-01130-6.pdfCitation Count: 13
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OPENTitle: ND0612 (levodopa/carbidopa for subcutaneous infusion) in patients with Parkinson's disease and motor response fluctuations: A randomized, placebo-controlled phase 2 studyJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 91Issue #:Start Page: 139End Page: 145Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1016/j.parkreldis.2021.09.024Best OA location URL: http://www.prd-journal.com/article/S1353802021003539/pdfCitation Count: 32
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OPENTitle: Nigral diffusivity, but not free water, correlates with iron content in Parkinson’s diseaseJournal Name: Brain CommunicationsPublisher: Oxford University Press (OUP)Vol: 3Issue #: 4Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1093/braincomms/fcab251Best OA location URL: https://academic.oup.com/braincomms/article-pdf/3/4/fcab251/41152899/fcab251.pdfCitation Count: 6
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RESTRICTEDTitle: Parkinson Disease: Translating Insights from Molecular Mechanisms to NeuroprotectionJournal Name: Pharmacological ReviewsPublisher: American Society for Pharmacology & Experimental Therapeutics (ASPET)Vol: 73Issue #: 4Start Page: 1204End Page: 1268Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1124/pharmrev.120.000189Best OA location URL: https://pharmrev.aspetjournals.org/content/pharmrev/73/4/1204.full.pdfCitation Count: 10
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RESTRICTEDTitle: Restoring lost nigrostriatal fibers in Parkinson’s disease based on clinically-inspired design criteriaJournal Name: Brain Research BulletinPublisher: Elsevier BVVol: 175Issue #:Start Page: 168End Page: 185Publication Date:Open Access(OA) Status: RESTRICTEDLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.brainresbull.2021.07.016Best OA location URL: https://doi.org/10.1016/j.brainresbull.2021.07.016Citation Count: 15
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RESTRICTEDTitle: Small Molecule Metabolites at the Host–Microbiota InterfaceJournal Name: The Journal of ImmunologyPublisher: The American Association of ImmunologistsVol: 207Issue #: 7Start Page: 1725End Page: 1733Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.4049/jimmunol.2100528Best OA location URL: https://www.jimmunol.org/content/jimmunol/207/7/1725.full.pdfCitation Count: 16
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RESTRICTEDTitle: Tardive Dyskinesia in Older Persons Taking AntipsychoticsJournal Name: Neuropsychiatric Disease and TreatmentPublisher: Informa UK LimitedVol: Volume 17Issue #:Start Page: 3127End Page: 3134Publication Date:Open Access(OA) Status: RESTRICTEDLicense: cc-by-ncDOI - Digital Object Identifier: 10.2147/ndt.s328301Best OA location URL: https://www.dovepress.com/getfile.php?fileID=74946Citation Count: 10
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OPENTitle: Transcriptional signatures in iPSC-derived neurons are reproducible across labs when differentiation protocols are closely matchedJournal Name: Stem Cell ResearchPublisher: Elsevier BVVol: 56Issue #:Start Page: 102558End Page: 102558Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.scr.2021.102558Best OA location URL: https://doi.org/10.1016/j.scr.2021.102558Citation Count: 3
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OPENTitle: Proposed research criteria for prodromal behavioural variant frontotemporal dementiaJournal Name: BrainPublisher: Oxford University Press (OUP)Vol: 145Issue #: 3Start Page: 1079End Page: 1097Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.1093/brain/awab365Best OA location URL: https://academic.oup.com/brain/article-pdf/145/3/1079/43500015/awab365.pdfCitation Count: 49
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OPENTitle: Salivary Lactoferrin Expression in a Mouse Model of Alzheimer’s DiseaseJournal Name: Frontiers in ImmunologyPublisher: Frontiers Media SAVol: 12Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fimmu.2021.749468Best OA location URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.749468/pdfCitation Count: 10
- Sphingolipid changes in Parkinson L444P GBA mutation fibroblasts promote α-synuclein aggregation2021OPENTitle: Sphingolipid changes in Parkinson L444P GBA mutation fibroblasts promote α-synuclein aggregationJournal Name: BrainPublisher: Oxford University Press (OUP)Vol: 145Issue #: 3Start Page: 1038End Page: 1051Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc, cc-by-ncDOI - Digital Object Identifier: 10.1093/brain/awab371Best OA location URL: https://academic.oup.com/brain/article-pdf/145/3/1038/43499976/awab371.pdfCitation Count: 41
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OPENTitle: Subthalamic Peak Beta Ratio Is Asymmetric in Glucocerebrosidase Mutation Carriers With Parkinson's Disease: A Pilot StudyJournal Name: Frontiers in NeurologyPublisher: Frontiers Media SAVol: 12Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fneur.2021.723476Best OA location URL: https://www.frontiersin.org/articles/10.3389/fneur.2021.723476/pdfCitation Count: 6
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OPENTitle: Cluster Analysis of Categorical Variables of Parkinson’s Disease PatientsJournal Name: Brain SciencesPublisher: MDPI AGVol: 11Issue #: 10Start Page: 1290End Page: 1290Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3390/brainsci11101290Best OA location URL: https://www.mdpi.com/2076-3425/11/10/1290/pdfCitation Count: 2
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OPENTitle: Kinetics of alpha-synuclein depletion in three brain regions following conditional pan-neuronal inactivation of the encoding gene (Snca) by tamoxifen-induced Cre-recombination in adult miceJournal Name: Transgenic ResearchPublisher: Springer Science and Business Media LLCVol: 30Issue #: 6Start Page: 867End Page: 873Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1007/s11248-021-00286-3Best OA location URL: https://link.springer.com/content/pdf/10.1007/s11248-021-00286-3.pdfCitation Count: 2
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OPENTitle: Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagyJournal Name: eLifePublisher: eLife Sciences Publications, LtdVol: 10Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.7554/elife.72328Best OA location URL: https://doi.org/10.7554/elife.72328Citation Count: 82
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RESTRICTEDTitle: Screening of GBA Mutations in Nigerian Patients with Parkinson's DiseaseJournal Name: Movement DisordersPublisher: WileyVol: 36Issue #: 12Start Page: 2971End Page: 2973Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1002/mds.28803Citation Count: 5
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OPENTitle: Screening of Parkinson’s Disease Using Geometric Features Extracted from Spiral DrawingsJournal Name: Brain SciencesPublisher: MDPI AGVol: 11Issue #: 10Start Page: 1297End Page: 1297Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3390/brainsci11101297Best OA location URL: https://www.mdpi.com/2076-3425/11/10/1297/pdf?version=1634005590Citation Count: 11
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OPENTitle: Contribution of rare variant associations to neurodegenerative disease presentationJournal Name: npj Genomic MedicinePublisher: Springer Science and Business Media LLCVol: 6Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41525-021-00243-3Best OA location URL: https://www.nature.com/articles/s41525-021-00243-3.pdfCitation Count: 17
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RESTRICTEDTitle: Current directions in tau research: Highlights from Tau 2020Journal Name: Alzheimer's & DementiaPublisher: WileyVol: 18Issue #: 5Start Page: 988End Page: 1007Publication Date:Open Access(OA) Status: RESTRICTEDLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1002/alz.12452Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.12452Citation Count: 46
- Factors associated with impaired quality of life three months after being diagnosed with COVID-192021OPENTitle: Factors associated with impaired quality of life three months after being diagnosed with COVID-19Journal Name: Quality of Life ResearchPublisher: Springer Science and Business Media LLCVol: 31Issue #: 5Start Page: 1401End Page: 1414Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1007/s11136-021-02998-9Best OA location URL: https://link.springer.com/content/pdf/10.1007/s11136-021-02998-9.pdfCitation Count: 32
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OPENTitle: Severity of Downgaze Palsy in the Context of Disease Duration Could Estimate Survival Duration in Patients With Progressive Supranuclear PalsyJournal Name: Frontiers in NeurologyPublisher: Frontiers Media SAVol: 12Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fneur.2021.736784Best OA location URL: https://www.frontiersin.org/articles/10.3389/fneur.2021.736784/pdfCitation Count: 3
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OPENTitle: Structural basis for the specificity of PPM1H phosphatase for Rab GTPasesJournal Name: EMBO reportsPublisher: Springer Science and Business Media LLCVol: 22Issue #: 11Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.15252/embr.202152675Best OA location URL: https://doi.org/10.15252/embr.202152675Citation Count: 16
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RESTRICTEDTitle: Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's diseaseJournal Name: Alzheimer's & DementiaPublisher: WileyVol: 18Issue #: 4Start Page: 824End Page: 857Publication Date:Open Access(OA) Status: RESTRICTEDLicense: cc-by-ncDOI - Digital Object Identifier: 10.1002/alz.12422Best OA location URL: https://escholarship.org/content/qt6rm979w3/qt6rm979w3.pdf?t=rffe31Citation Count: 65
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OPENTitle: Relationships between Mitochondrial Function, AMPK, and TORC1 Signaling in Lymphoblasts with Premutation Alleles of the FMR1 GeneJournal Name: International Journal of Molecular SciencesPublisher: MDPI AGVol: 22Issue #: 19Start Page: 10393End Page: 10393Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3390/ijms221910393Best OA location URL: https://www.mdpi.com/1422-0067/22/19/10393/pdf?version=1632737629Citation Count: 4
- The Power of Musification: Sensor‐Based Music Feedback Improves Arm Swing in Parkinson's Disease2021OPENTitle: The Power of Musification: Sensor‐Based Music Feedback Improves Arm Swing in Parkinson's DiseaseJournal Name: Movement Disorders Clinical PracticePublisher: WileyVol: 8Issue #: 8Start Page: 1240End Page: 1247Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1002/mdc3.13352Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mdc3.13352Citation Count: 10
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OPENTitle: 32nd International Symposium on the Autonomic Nervous SystemJournal Name: Clinical Autonomic ResearchPublisher: Springer Science and Business Media LLCVol: 31Issue #: 5Start Page: 591End Page: 644Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s10286-021-00822-5Best OA location URL: https://link.springer.com/content/pdf/10.1007/s10286-021-00822-5.pdfCitation Count: 2
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OPENTitle: Measuring Structural Racism: A Guide for Epidemiologists and Other Health ResearchersJournal Name: American Journal of EpidemiologyPublisher: Oxford University Press (OUP)Vol: 191Issue #: 4Start Page: 539End Page: 547Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/aje/kwab239Best OA location URL: https://academic.oup.com/aje/article-pdf/191/4/539/43609257/kwab239.pdfCitation Count: 222
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OPENTitle: Effect of the Histone Deacetylase Inhibitor FRM-0334 on Progranulin Levels in Patients With Progranulin Gene HaploinsufficiencyJournal Name: JAMA Network OpenPublisher: American Medical Association (AMA)Vol: 4Issue #: 9Start Page: e2125584End Page: e2125584Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1001/jamanetworkopen.2021.25584Best OA location URL: https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2784478/ljubenkov_2021_oi_210757_1631885845.47256.pdfCitation Count: 19
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OPENTitle: Pandemic Tic‐like Behaviors Following Social Media ConsumptionJournal Name: Movement DisordersPublisher: WileyVol: 36Issue #: 12Start Page: 2932End Page: 2935Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1002/mds.28800Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mds.28800Citation Count: 60
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OPENTitle: Parkin interacting substrate phosphorylation by c-Abl drives dopaminergic neurodegenerationJournal Name: BrainPublisher: Oxford University Press (OUP)Vol: 144Issue #: 12Start Page: 3674End Page: 3691Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/brain/awab356Best OA location URL: https://academic.oup.com/brain/article-pdf/144/12/3674/42004692/awab356.pdfCitation Count: 18
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OPENTitle: SRCP: a comprehensive pipeline for accurate annotation and quantification of circRNAsJournal Name: Genome BiologyPublisher: Springer Science and Business Media LLCVol: 22Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s13059-021-02497-7Best OA location URL: https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-021-02497-7Citation Count: 13