4601 - 4650 of 7916 Results
Title
Year
- Co-occurring WARS2 and CHRNA6 mutations in a child with a severe form of infantile parkinsonism2020OPENTitle: Co-occurring WARS2 and CHRNA6 mutations in a child with a severe form of infantile parkinsonismJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 72Issue #:Start Page: 75End Page: 79Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2020.02.003Best OA location URL: https://discovery.ucl.ac.uk/10095066/3/Kurian_CHRNA6.pdfCitation Count: 19
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OPENTitle: Brain perfusion patterns are altered in chronic knee pain: a spatial covariance analysis of arterial spin labelling MRIJournal Name: PainPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 161Issue #: 6Start Page: 1255End Page: 1263Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1097/j.pain.0000000000001829Best OA location URL: https://journals.lww.com/pain/Fulltext/2020/06000/Brain_perfusion_patterns_are_altered_in_chronic.13.aspxCitation Count: 17
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OPENTitle: LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosisJournal Name: eLifePublisher: eLife Sciences Publications, LtdVol: 9Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.7554/elife.51071Best OA location URL: https://doi.org/10.7554/elife.51071Citation Count: 91
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OPENTitle: Pathology‐Proven Corticobasal Degeneration Presenting as Richardson's SyndromeJournal Name: Movement Disorders Clinical PracticePublisher: WileyVol: 7Issue #: 3Start Page: 267End Page: 272Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mdc3.12900Best OA location URL: https://movementdisorders.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mdc3.12900Citation Count: 7
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OPENTitle: Safety of Levodopa-Carbidopa Intestinal Gel Treatment in Patients with Advanced Parkinson’s Disease Receiving ≥2000 mg Daily Dose of LevodopaJournal Name: Parkinson's DiseasePublisher: Hindawi LimitedVol: 2020Issue #:Start Page: 1End Page: 11Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1155/2020/9716317Best OA location URL: https://doi.org/10.1155/2020/9716317Citation Count: 15
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OPENTitle: Cerebrospinal fluid proteomics implicates the granin family in Parkinson’s diseaseJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 10Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41598-020-59414-4Best OA location URL: https://www.nature.com/articles/s41598-020-59414-4.pdfCitation Count: 67
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OPENTitle: Impulse control and related behaviors in Parkinson’s disease with dementiaJournal Name: European Journal of NeurologyPublisher: WileyVol: 27Issue #: 6Start Page: 944End Page: 950Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/ene.14169Best OA location URL: https://discovery.ucl.ac.uk/10093209/3/Schrag_Manuscript_EJN_revised_29-01-2020%5B1%5D.pdfCitation Count: 17
- Longitudinal follow-up with VIM thalamic deep brain stimulation for dystonic or essential tremor2020OPENTitle: Longitudinal follow-up with VIM thalamic deep brain stimulation for dystonic or essential tremorJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 94Issue #: 10Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0000000000008875Best OA location URL: https://europepmc.org/articles/pmc7238918?pdf=renderCitation Count: 67
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RESTRICTEDTitle: Diagnosis and Treatment of Parkinson DiseaseJournal Name: JAMAPublisher: American Medical Association (AMA)Vol: 323Issue #: 6Start Page: 548End Page: 548Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1001/jama.2019.22360Citation Count: 1523
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OPENTitle: Non-motor symptoms and striatal dopamine transporter binding in early Parkinson's diseaseJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 72Issue #:Start Page: 23End Page: 30Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2020.02.001Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222918Citation Count: 24
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OPENTitle: Palatal myoclonus, abnormal eye movements, and olivary hypertrophy in GAD65-related disorderJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 94Issue #: 6Start Page: 273End Page: 275Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0000000000008926Best OA location URL: https://zenodo.org/record/5915142Citation Count: 5
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RESTRICTEDTitle: Wearable-based mobility monitoring: the long road aheadJournal Name: The Lancet NeurologyPublisher: Elsevier BVVol: 19Issue #: 5Start Page: 378End Page: 379Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/s1474-4422(20)30033-8Citation Count: 27
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OPENTitle: Child Neurology: Genetically determined dystonias with childhood onsetJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 94Issue #: 20Start Page: 892End Page: 895Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0000000000009040Best OA location URL: https://n.neurology.org/content/neurology/94/20/892.full.pdfCitation Count: 4
- Lysosome and Inflammatory Defects in GBA1 ‐Mutant Astrocytes Are Normalized by LRRK2 Inhibition2020OPENTitle: Lysosome and Inflammatory Defects in GBA1 ‐Mutant Astrocytes Are Normalized by LRRK2 InhibitionJournal Name: Movement DisordersPublisher: WileyVol: 35Issue #: 5Start Page: 760End Page: 773Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.27994Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167931Citation Count: 82
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RESTRICTEDTitle: Neuropathological Findings in Parkinson's Disease With Mild Cognitive ImpairmentJournal Name: Movement DisordersPublisher: WileyVol: 35Issue #: 5Start Page: 845End Page: 850Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1002/mds.27991Citation Count: 18
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OPENTitle: Teaching NeuroImages: The dentate sign in subacute cerebellar ataxiaJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 94Issue #: 8Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0000000000009006Best OA location URL: https://n.neurology.org/content/neurology/94/8/e878.full.pdfCitation Count: 2
- Do Parkinson disease subject and caregiver-reported Epworth sleepiness scale reponses correlate?2020OPENTitle: Do Parkinson disease subject and caregiver-reported Epworth sleepiness scale reponses correlate?Journal Name: Clinical Neurology and NeurosurgeryPublisher: Elsevier BVVol: 192Issue #:Start Page: 105728End Page: 105728Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.clineuro.2020.105728Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183413Citation Count: 2
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RESTRICTEDTitle: Optimizing red blood cell protein extraction for biomarker quantitation with mass spectrometryJournal Name: Analytical and Bioanalytical ChemistryPublisher: Springer Science and Business Media LLCVol: 412Issue #: 8Start Page: 1879End Page: 1892Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1007/s00216-020-02439-5Citation Count: 12
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OPENTitle: APOE genotype regulates pathology and disease progression in synucleinopathyJournal Name: Science Translational MedicinePublisher: American Association for the Advancement of Science (AAAS)Vol: 12Issue #: 529Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1126/scitranslmed.aay3069Best OA location URL: https://stm.sciencemag.org/content/scitransmed/12/529/eaay3069.full.pdfCitation Count: 120
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OPENTitle: Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophyJournal Name: NaturePublisher: Springer Science and Business Media LLCVol: 578Issue #: 7794Start Page: 273End Page: 277Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/s41586-020-1984-7Best OA location URL: https://europepmc.org/articles/pmc7066875?pdf=renderCitation Count: 540
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OPENTitle: The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBACJournal Name: Science SignalingPublisher: American Association for the Advancement of Science (AAAS)Vol: 13Issue #: 617Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1126/scisignal.aav1256Best OA location URL: https://stke.sciencemag.org/content/sigtrans/13/617/eaav1256.full.pdfCitation Count: 18
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OPENTitle: Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological studyJournal Name: Nature CommunicationsPublisher: Springer Science and Business Media LLCVol: 11Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41467-019-14279-8Best OA location URL: https://www.nature.com/articles/s41467-019-14279-8.pdfCitation Count: 306
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RESTRICTEDTitle: Practical Evaluation and Management of Insomnia in Parkinson's Disease: A ReviewJournal Name: Movement Disorders Clinical PracticePublisher: WileyVol: 7Issue #: 3Start Page: 250End Page: 266Publication Date:Open Access(OA) Status: RESTRICTEDLicense: cc-by-ncDOI - Digital Object Identifier: 10.1002/mdc3.12899Best OA location URL: https://doi.org/10.1002/mdc3.12899Citation Count: 21
- RGS Proteins as Critical Regulators of Motor Function and Their Implications in Parkinson’s Disease2020RESTRICTEDTitle: RGS Proteins as Critical Regulators of Motor Function and Their Implications in Parkinson’s DiseaseJournal Name: Molecular PharmacologyPublisher: American Society for Pharmacology & Experimental Therapeutics (ASPET)Vol: 98Issue #: 6Start Page: 730End Page: 738Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1124/mol.119.118836Best OA location URL: https://molpharm.aspetjournals.org/content/molpharm/98/6/730.full.pdfCitation Count: 12
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OPENTitle: Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2Journal Name: StructurePublisher: Elsevier BVVol: 28Issue #: 4Start Page: 406End Page: 417.e6Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1016/j.str.2020.01.005Best OA location URL: http://www.cell.com/article/S0969212620300058/pdfCitation Count: 70
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OPENTitle: Tensor decomposition of stimulated monocyte and macrophage gene expression profiles identifies neurodegenerative disease-specific trans-eQTLsJournal Name: PLOS GeneticsPublisher: Public Library of Science (PLoS)Vol: 16Issue #: 2Start Page: e1008549End Page: e1008549Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1371/journal.pgen.1008549Best OA location URL: https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1008549&type=printableCitation Count: 21
- Abstracts2020OPENTitle: AbstractsJournal Name: Movement Disorders Clinical PracticePublisher: WileyVol: 7Issue #: S1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mdc3.12905Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mdc3.12905Citation Count: 2
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OPENTitle: Analysis of common and rare VPS13C variants in late-onset Parkinson diseaseJournal Name: Neurology GeneticsPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 6Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1212/nxg.0000000000000385Best OA location URL: https://ng.neurology.org/content/nng/6/1/385.full.pdfCitation Count: 19
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OPENTitle: Cognition in multiple system atrophy: a single‐center cohort studyJournal Name: Annals of Clinical and Translational NeurologyPublisher: WileyVol: 7Issue #: 2Start Page: 219End Page: 228Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1002/acn3.50987Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.50987Citation Count: 34
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RESTRICTEDTitle: Effects of a community-based Exercise Program On mobility, balance, cognition, sleep, Activities of Daily living, and Quality of Life in PD: A Pilot StudyJournal Name: Neurodegenerative Disease ManagementPublisher: Informa UK LimitedVol: 10Issue #: 1Start Page: 27End Page: 39Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.2217/nmt-2019-0027Citation Count: 16
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OPENTitle: Grey matter abnormalities are associated only with severe cognitive decline in early stages of Parkinson's diseaseJournal Name: CortexPublisher: Elsevier BVVol: 123Issue #:Start Page: 1End Page: 11Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.cortex.2019.09.015Best OA location URL: https://cris.maastrichtuniversity.nl/files/76215206/Leentjens_2020_Grey_matter_abnormalities_are_associated.pdfCitation Count: 16
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OPENTitle: Keep calm and beam on? Unmet needs in radiotherapy and deep brain stimulationJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 71Issue #:Start Page: 15End Page: 16Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2020.01.005Best OA location URL: https://repository.ubn.ru.nl//bitstream/handle/2066/220676/220676.pdfCitation Count: 1
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RESTRICTEDTitle: Management of Orthostatic HypotensionJournal Name: CONTINUUM: Lifelong Learning in NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 26Issue #: 1Start Page: 154End Page: 177Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1212/con.0000000000000816Best OA location URL: https://europepmc.org/articles/pmc7339914?pdf=renderCitation Count: 44
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RESTRICTEDTitle: Multidisciplinary Care to Optimize Functional Mobility in Parkinson DiseaseJournal Name: Clinics in Geriatric MedicinePublisher: Elsevier BVVol: 36Issue #: 1Start Page: 159End Page: 172Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.cger.2019.09.008Best OA location URL: https://repository.ubn.ru.nl//bitstream/handle/2066/214080/214080.pdfCitation Count: 19
- Optimizing intracellular antibodies (intrabodies/nanobodies) to treat neurodegenerative disorders2020RESTRICTEDTitle: Optimizing intracellular antibodies (intrabodies/nanobodies) to treat neurodegenerative disordersJournal Name: Neurobiology of DiseasePublisher: Elsevier BVVol: 134Issue #:Start Page: 104619End Page: 104619Publication Date:Open Access(OA) Status: RESTRICTEDLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.nbd.2019.104619Best OA location URL: https://doi.org/10.1016/j.nbd.2019.104619Citation Count: 57
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RESTRICTEDTitle: Orthostatic Hypotension in Parkinson DiseaseJournal Name: Clinics in Geriatric MedicinePublisher: Elsevier BVVol: 36Issue #: 1Start Page: 53End Page: 67Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.cger.2019.09.002Best OA location URL: https://europepmc.org/articles/pmc7029426?pdf=renderCitation Count: 48
- Renal Dysfunction Might Be a Marker of Cardiovascular Dysautonomia in Prodromal Α‐Synucleinopathies2020OPENTitle: Renal Dysfunction Might Be a Marker of Cardiovascular Dysautonomia in Prodromal Α‐SynucleinopathiesJournal Name: Movement DisordersPublisher: WileyVol: 35Issue #: 2Start Page: 374End Page: 374Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.27840Best OA location URL: https://europepmc.org/articles/pmc7122792?pdf=renderCitation Count: 0
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RESTRICTEDTitle: Stem-Cell Research of Parkinson Disease: Bibliometric Analysis of Research Productivity from 1999 to 2018Journal Name: World NeurosurgeryPublisher: Elsevier BVVol: 134Issue #:Start Page: e405End Page: e411Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.wneu.2019.10.087Citation Count: 11
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RESTRICTEDTitle: Tears – more to them than meets the eye: why tears are a good source of biomarkers in Parkinson's diseaseJournal Name: Biomarkers in MedicinePublisher: Informa UK LimitedVol: 14Issue #: 2Start Page: 151End Page: 163Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.2217/bmm-2019-0364Citation Count: 17
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OPENTitle: Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial CellsJournal Name: Frontiers in ImmunologyPublisher: Frontiers Media SAVol: 11Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fimmu.2020.00033Citation Count: 58
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OPENTitle: Subcortical Intermittent Theta-Burst Stimulation (iTBS) Increases Theta-Power in Dorsolateral Prefrontal Cortex (DLPFC)Journal Name: Frontiers in NeurosciencePublisher: Frontiers Media SAVol: 14Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fnins.2020.00041Citation Count: 21
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OPENTitle: Mild dopa-responsive dystonia in heterozygous tyrosine hydroxylase mutation carrier: Evidence of symptomatic enzyme deficiency?Journal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 71Issue #:Start Page: 44End Page: 45Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1016/j.parkreldis.2020.01.017Best OA location URL: http://www.prd-journal.com/article/S1353802020300237/pdfCitation Count: 7
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OPENTitle: Analysis of neurodegenerative disease-causing genes in dementia with Lewy bodiesJournal Name: Acta Neuropathologica CommunicationsPublisher: Springer Science and Business Media LLCVol: 8Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s40478-020-0879-zBest OA location URL: https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-020-0879-z.pdfCitation Count: 28
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OPENTitle: Relationship of Movement Disorders Society–Unified Parkinson's Disease Rating Scale Nonmotor Symptoms to Cognitive Functioning in Patients with Parkinson's DiseaseJournal Name: Movement Disorders Clinical PracticePublisher: WileyVol: 7Issue #: 3Start Page: 279End Page: 283Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mdc3.12902Best OA location URL: https://movementdisorders.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mdc3.12902Citation Count: 5
- T cell infiltration in both human multiple system atrophy and a novel mouse model of the disease2020OPENTitle: T cell infiltration in both human multiple system atrophy and a novel mouse model of the diseaseJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 139Issue #: 5Start Page: 855End Page: 874Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1007/s00401-020-02126-wBest OA location URL: https://link.springer.com/content/pdf/10.1007/s00401-020-02126-w.pdfCitation Count: 76
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OPENTitle: An Assessment of LRRK2 Serine 935 Phosphorylation in Human Peripheral Blood Mononuclear Cells in Idiopathic Parkinson’s Disease and G2019S LRRK2 CohortsJournal Name: Journal of Parkinson's DiseasePublisher: SAGE PublicationsVol: 10Issue #: 2Start Page: 623End Page: 629Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.3233/jpd-191786Best OA location URL: https://content.iospress.com:443/download/journal-of-parkinsons-disease/jpd191786?id=journal-of-parkinsons-disease%2Fjpd191786Citation Count: 38
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OPENTitle: Exercise Reverses Dysregulation of T-Cell-Related Function in Blood Leukocytes of Patients With Parkinson's DiseaseJournal Name: Frontiers in NeurologyPublisher: Frontiers Media SAVol: 10Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fneur.2019.01389Citation Count: 9
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RESTRICTEDTitle: Selective metabotropic glutamate receptor 2 positive allosteric modulation alleviates L-DOPA-induced psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmosetJournal Name: European Journal of PharmacologyPublisher: Elsevier BVVol: 873Issue #:Start Page: 172957End Page: 172957Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.ejphar.2020.172957Citation Count: 25
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OPENTitle: Gastrointestinal symptoms are predictive of trajectories of cognitive functioning in de novo Parkinson's diseaseJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 72Issue #:Start Page: 7End Page: 12Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2020.01.009Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179075Citation Count: 51