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Translation of the Neuroprotective Immune Modulator LBT-3627 into First-In-Human Studies
… well as people with PD who exhibit a dysfunctional immune system. Participants will be treated with a single dose of … in terms of future PD clinical trials. … Adaptive immune system … autoimmunity … Clinical trials … disease …
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Episode 9: Examining the Proposed Biological Definition of Neuronal Alpha-Synuclein Disease and Staging System with Lana Chahine
February 20, 2024
… (NSD) has been proposed, along with an integrated staging system (NSD-ISS). In this interview, we discuss the … biologic definition for Parkinson’s disease and the staging system with Dr. Lana Chanine, one of the lead authors of the …
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Using Machine Learning on Longitudinal Data from Multiple Cohorts to Determine Biological Subtypes and Prediction Scores for Parkinson’s Disease
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Proteomic analysis of accumulated proteins in dopaminergic neurons using a pre-clinical model ofubiquitin-proteasome system dysfunction
… that degrades them. Failure of this protein degradation system in dopamine neurons is believed to contribute to the …
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Effects of noradrenergic or serotoninergic system lesions combined with NS lesions on rodent models of 'non-motor'-like symptoms
… little attention. Damage to all these neuronal systems would contribute to comorbid anxiety, depression and …
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Evaluation of the Inflammation-blocking Drug Tolebrutinib as a Novel Disease-modifying Therapeutic for Parkinson's Disease
… the effectiveness of Tolebrutinib in cell culture and in multiple preclinical animal models of PD. We will determine … … Neuroprotective/Regenerative … peripheral immune system … Therapeutic Pipeline Program … Richard Gordon, PhD, …