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Steve Horvath, ScD, PhD
… develops and applies biostatistical, computational and systems biologic data analysis methods. He has extensive … His lab is working on enhancing DNAm age estimators along multiple dimensions to make them more predictive of health …
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Christine Stadelmann, MD
… in characterizing the disease mechanisms of progressive multiple sclerosis focusing on the innate immune system, in particular microglial cells. Other research …
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Gut-to-brain Circuit Contributions to Parkinson-like Phenotypes in Disease Models
… the connections between neurons in the enteric nervous system, which regulates the gastrointestinal tract. This … Parkinson’s Disease: Using powerful new technologies across multiple PD-relevant model systems, this project could …
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Development of an Adult Adherent Allogeneic Stem Cell Product for Treatment of Parkinson's Disease
… by the FDA for Phase I studies in humans, works through multiple mechanisms of benefit, including immune modulation … neuroprotection, in pre-clinical models of central nervous system (CNS) injury and disease. Translationally relevant …
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Evaluation of a Specific DAT Inhibitor in Pre-clinical Models of Parkinson's Disease
… disease with deficits in motor, sleep, cognitive, and other systems, we propose to establish a “platform” of models to … in combination with levodopa may improve PD treatment in multiple ways. During the day, MLR-1017 administration would …
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Proof-of-concept Study for the Development of Non-invasive Immunotherapy for Parkinson’s Disease: Intranasal Targeting of Immunoglobulin G Antibodies and Fragments to the CNS
… (PD). However, achieving reliable, chronic central nervous system (CNS) delivery for macromolecules such as antibodies … peripheral tissue levels will be measured and mapped using multiple technologies. Control experiments will be performed …