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Fidias Leon-Sarmiento, MD, PhD
… his current research focuses on human corticospinal (brain system) physiology (function), particularly brainstem and … numerous awards for his scientific achievements, including multiple awards from international institutions. …
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Steve Xu, MD
… had direct experience developing physiological monitoring systems that incorporate multiple sensors requiring hardware and software …
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Pharmacokinetics and CNS Distribution of IgG Antibodies: Quantitative Comparison of Blood-brain, Blood-CSF and CSF-brain Relationships After Intranasal and Intravascular Dosing
… (PD). However, achieving reliable, chronic central nervous system (the brain and spinal cord) delivery for molecules, … peripheral tissue levels will be measured and mapped using multiple techniques. In summary, we will comprehensively …
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Development of a Protein Biomarker Panel to Measure Parkinson’s Disease Heterogeneity and Progression
… Octave has developed a precision-care platform for multiple sclerosis that includes a custom biomarker assay … signatures with relevant endpoints and employing a systems biology approach to corroborating pathophysiology. …
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Optogenetics-based, Photo-switchable Model of Parkinson’s Disease for Drug Screening
… bidirectional control of defined brain circuits in intact systems. Project Description: We will use technical … in a less advanced model; tunability (so it recapitulates multiple stages of the disease from mild to advanced in the …
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Exosomal Delivery of shRNA Minicircles to Halt Neurodegeneration and Parkinson's
… of Parkinson's disease (PD). We have developed a novel system to treat brain diseases using exosomes, which are … from the same patient to avoid problems associated with multiple dose treatments. Using cell and pre-clinical …