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Clinical Development of AKST4290 as a Novel Parkinson’s Therapeutic
… Study Rationale: There is clear evidence that the immune system plays an important role in the development and … pathologic inflammation, to assess the potential effects on multiple symptoms associated with Parkinson's disease. Pre - …
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Development of a Biomarker Platform for Parkinson’s Disease Using Patient-derived Cells
… addresses this need by developing a unique human cellular system for the early identification and study of … investigator plans to grow skin fibroblasts derived from multiple Parkinson's patients and age-matched controls and …
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Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model
June 9, 2021
… Multiple mutations have been described in the human GBA1 … and inflammation were not observed in the nigrostriatal system of this model. In summary, the GBA1 D409V KI mouse …
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Caleb Webber, PhD
… may be best understood through the contribution of multiple genes to multiple disease-relevant processes. Thus, Dr. Webber does …
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Measuring Parkinson’s Protein throughout Body
March 16, 2016
… Today, The Michael J. Fox Foundation (MJFF) launched the Systemic Synuclein Sampling Study (S4) to further … research at the Institute for Neurodegenerative Disorders. “Multiple studies have demonstrated the significance of …
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Pharmacological Testing of Nurr1 Agonists in Pre-clinical Models of Parkinson's Disease
… Björklund (Sweden). The Isacson laboratory will use a “multiple hit” model in which DA neuronal loss in the … of human wild type alpha-synuclein in the nigrostriatal system induces progressive loss of DA neurons that …