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Brainstem and Olfactory System Biomarkers of Early Parkinson's Disease
… earliest brain pathology of PD occurs outside of the motor system, namely in the olfactory bulbs (brain regions that …
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Characterization of Parkinson’s Disease Clinical Subtypes Using Multiple Immunologic and Genetic Markers
… We hypothesize that genetic data related to the immune system holds valuable information regarding the onset and … based on the available genetic data, focusing on the immune system. From these characterizations, we will extract …
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Does Sporadic Parkinson's Disease Begin in the Enteric Nervous System?
… involves a few nerve cell types within the human nervous system. A retrospective cross-sectional post-mortem staging … Parkinson's disease begins outside of the central nervous system. Our project aims to test whether the enteric nervous …
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Eureka Aleart: Small Molecules Found to Protect Cells in Multiple Models of Parkinson's Disease
December 28, 2009
… of protecting cells from alpha-synuclein toxicity in multiple models of Parkinson's disease, according to … this research, we used yeast as a Parkinson's disease model system to identify the compounds that really work in two …
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Evaluating the Therapeutic Potential of the Systemic Antagonism of Dopamine Receptor D3
… for dopamine (DR), a substance produced by the nervous system, plays a pivotal role in the death of brain cells … if inhibiting the dopamine receptor in this more complex system still provides a therapeutic benefit. Our goal is to …
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The First Biological Staging System for Parkinson’s: A Research Accelerator for the Field
January 23, 2024
… think about the disease. The framework then describes a system for staging the disease that accounts for Parkinson’s … as the neuronal alpha-synuclein disease integrated staging system (NSD-ISS), is the first biological staging system for …