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A New Pharmaceutical Target for Mono and Add-on Therapy in Parkinson’s Disease
… Description: We have recently discovered multiple small molecules that are capable of inhibiting the … A novel medicine for PD not targeting the dopamine system of the brain could improve patient’s quality of life. …
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Development of Nanobodies as Novel Tools to Characterize LRRK2 as a Potential Drug Target for Parkinson's Disease
… (accelerates chemical reactions) functions. Targeting the multiple enzymatic functions of LRRK2 represents a very … fragments derived from a special type of antibodies (immune system cells) present in camelids such as llamas. In recent …
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Using “Nanobodies” to Prevent Formation of Intracellular Alpha-synuclein Aggregates
… particular, we will inhibit proteasomes and lysosomes, two systems cells use to degrade damaged and worn-out … its penetration and distribution. Finally, we will use multiple techniques to assess whether protection of …
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Characterizing the Immune Cells Present in the Blood and Cerebrospinal Fluid of People with Parkinson's Disease Associated with Mutations in LRRK2
… We hypothesize that specific changes in the immune system play a role in the development and progression of PD … from individuals with varying forms of PD. We will then use multiple single-cell analytic techniques to catalog the …
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Lamp-2a as a Therapeutic Target in Parkinson's Disease
… Objective/Rationale: Multiple pieces of evidence converge on the notion that … model, and whether induction of this degradation system in vivo can be used to get rid of excess …
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Screen for Novel Glucocerebrosidase-Interacting Parkinson's Genes
… characteristic Parkinson’s disease pathology in the nervous system, as well as for motor problems (such as difficulty … Parkinson’s disease. With this study we expect to identify multiple genes with previously unrecognized roles in …