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Two-Hit Pre-clinical Models for Parkinson’s Disease
… We aim to generate pre-clinical models that incorporate multiple genetic defects found in PD patients. In terms of … littermate controls. Characterization of the dopaminergic system and the neurobiological basis for this phenomenon is …
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Direct Reprogramming of Functional, Induced Dopaminergic Neurons from Human Adult Somatic Cells
… state and re-establishing a functional dopaminergic system. Finally, some critical aspects of these neurons will … of disease-affected iDA neurons for studying in the dish multiple pathogenetic mechanisms of PD with relevant …
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Michael J. Fox Foundation for Parkinson’s Research Announces Promising Results, Next Steps for “Ken Griffin Alpha-synuclein Imaging Competition”
March 28, 2023
… visualize alpha-synuclein in living human patients with multiple system atrophy (a related parkinsonism). AC Immune is now advancing …
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Update on Alpha-synuclein Therapies in Clinical Trials
July 10, 2017
… . Harnessing the Power of the Immune System to Protect Cells AFFiRiS aims to harness the body's … This information is useful as this therapy may require multiple doses. Preventing Toxic Protein Clumps Neuropore is …
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Almira (Ellie) Chabi, MD
… International. Dr. Chabi leads programs across multiple therapeutic areas including neurology, immunology, … within Ophthalmology as well as Neuroscience leading to multiple successful NDA filings. In addition to expertise …
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Ghrelin - a Peripheral, Preclinical Biomarker for Parkinson's Disease
… cohorts, i.e. patients with diabetes mellitus type 2 and multiple sclerosis. For both conditions, ghrelin serum … potential. In addition, it is known that ghrelin acts on systems that frequently are also affected in PD …