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LRRK2 Variation in Parkinson's Disease
… have also been the driving force behind disease-model systems and the directed the therapeutic intervention … variant. We will also assess the possible role of multiple LRRK2 variants acting together to result in disease …
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Mapping Brain Response Patterns to Deep Brain Stimulation with FMRI
… (i.e., programmed). However, DBS programming often requires multiple clinic visits to test the large number of possible … DBS for Parkinson’s disease. The process of programming DBS systems takes numerous clinic visits, resulting in a long, …
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Support for your Collaboration on Proof-of-concept clinical trial on the use of the 5-HT1A/1B Partial Agonist Eltoprazine for Treatment of L-DOPA-induced Dyskinesias. - Linked to Bjorklund CIA 2009
… fewer and fewer dopamine terminals survive, another neuron system kicks in: the serotonin neurons. The serotonin … transmitter,” but in a non-physiological manner. Studies in multiple pre-clinical models of the disease have shown that …
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Developing Wiring Diagrams of the Brain-Body Connection
… the neural networks that control an example of each system. Hypothesis: Understanding the wiring diagrams that … we will study the celiac ganglion, which innervates multiple internal organs, including the esophagus, stomach, …
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Pre-clinical Development of a Parkinson's Disease Therapy Using a Glucagon-Like Peptide (GLP)-1 Receptor Agonist
… neurochemical, and histopathological deficits in multiple rodent models of PD. Exendin-4 has the potential to … A manuscript describing the effects of exendin-4 on multiple therapeutic endpoints, including neurobehavioral …
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Director of Prospect Research & Development
… programs Develop a replicable and scalable identification system for major and transformational gift prospects in the … experience in conducting quality prospect research for multiple audiences and stakeholders, including executive …