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MJFF Study Making Strides Toward Parkinson's Biomarker
April 13, 2017
… To meet this need, in 2016, MJFF launched the Systemic Synuclein Sampling Study (S4) , an observational … S4 is the first study to evaluate alpha-synuclein in multiple body fluids and tissues within the same person and …
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Biochemical Characterization of Full Length Human Recombinant LRRK1 and LRRK2
… is to make purified protein by combining expertise in multiple technologies from each of our collaborating … Our first step will be to genetically engineer a vector system that is derived from viruses to express the gene that …
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Increased Dopamine Turnover as a Manifestation of LRRK2 Mutation
… positron emission tomography (PET) to study the dopamine system in detail in people from families with different … onset; (ii) that this abnormality will affect people from multiple different families with LRRK2 mutations, …
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Gene Therapy to Restore Protein Imbalance in Parkinson's Disease
… to specific brain areas, avoiding the possible effects of systemic and chronic administration of ER stress-targeting … the brain due to their safety profile, as demonstrated in multiple clinical trials. In this project, we plan to …
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Ask the MD: Which DBS Device Is Right for Me?
December 4, 2018
… areas of the brain to lessen Parkinson's symptoms. DBS systems have three main components: Lead : This is a wire … (IPG): Also called the neurostimulator, the IPG is the system's battery and "brains." A clinician programs the IPG …
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Determining the Level of LRRK2 Inhibition Required for Therapeutic Efficacy
… has yet to be determined. This study will examine multiple levels of target engagement in a model of … linked to LRRK2 inhibition). Next, we will determine multiple doses of PFE360 that produce differing levels of …