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What We Fund: $100.4M toward Novel Approaches to Reduce Freezing of Gait and Improve Understanding of Parkinson’s Environment Risk Factors
December 18, 2024
… of Würzburg in Germany is developing an adaptive DBS system capable of detecting a freezing episode and … in the air are associated with developing PD . Called Multiple Air Pollutants in Parkinson’s Disease (MAP-PD), the …
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Patient, Research and Industry Leaders Propose Biological Definition and First Biological Staging for Parkinson’s Disease
January 23, 2024
… this new definition, the paper’s authors propose a staging system — the neuronal alpha-synuclein disease integrated … achieve a paradigm shift in how PD is defined and staged, multiple diverse stakeholders need to come together and …
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Determining the Level of LRRK2 Inhibition Required for Therapeutic Efficacy
… has yet to be determined. This study will examine multiple levels of target engagement in a model of … linked to LRRK2 inhibition). Next, we will determine multiple doses of PFE360 that produce differing levels of …
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Alpha-Synuclein Assay Standardization LEAPS
… blood, cerebrospinal fluid and saliva has been reported by multiple scientists using a variety of analytical … that have the necessary experience and expertise to assess multiple alpha-synuclein research assays for consistency of …
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Carole Ho
… tenure at Genentech, she led the successful development of multiple therapeutics that advanced to Phase III trials or were approved, including ocrelizumab for multiple sclerosis, lampalizumab for age-related macular …
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Characterization, Optimization and Validation of a Preformed Fibril Pre-clinical Model of Parkinson's Disease
… platform will allow for evaluation of treatment effects on multiple brain regions simultaneously to address non-motor … wide spread use and thereby provide a platform for multiple investigators to use the same platform from which …