The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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LRRK2 Biology Consortium, 2017Kinase Activity-mediated Changes in LRRK2-Parkinson's and Sporadic Parkinson's Cells and Rab Protein Function
Promising Outcomes of Original Grant:
Our previous studies have demonstrated deficits in cohesion, positioning, and polarity (important characteristics of cells that help regulate function) in... -
Research Grant, 2017Inflammation in Parkinson's Disease
Study Rationale:
The contribution of inflammation to Parkinson's disease (PD) is increasingly being recognized. However, the stage of the disease in which inflammation is prevalent and/or important...
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LRRK2 Biology Consortium, 2017Development of Nanobodies as Novel Tools to Characterize LRRK2 as a Potential Drug Target for Parkinson's Disease
Study Rationale:
Several genes play a crucial role in Parkinson's disease (PD). The most common genetic cause of PD is mutations in the gene encoding LRRK2, a very large and complex protein with... -
Research Grant, 2017Gene Therapy to Restore Protein Imbalance in Parkinson's Disease
Study Rationale:
Parkinson's disease (PD) is characterized by impairment of motor control as a result from extensive neuron death. The primary mechanism responsible for the progressive neuronal loss in... -
Research Grant, 2017External Validation of Proteos Alpha-synuclein Pre-formed Fibrils
Study Rationale:
A reliable, characterized and validated model of synucleinopathies (disorders in which there is an excessive accumulation of the protein alpha-synuclein) would provide a critical tool... -
Research Grant, 2017Optimization of Dopamine Compounds for the Treatment of L-DOPA-induced Dyskinesias (LIDs)
Promising Outcomes of Original Grant:
In our original proposal, we identified two chemical scaffolds (protein support structures) as dopamine receptor 4 (D4R) antagonists (compounds that block the...
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Our funding programs support basic, translational and clinical research from academia and industry.