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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Understanding LRRK2 Biology, 2009
    Characterization of LRRK2 Cellular and Signaling Pathways

    Objective/Rationale
    Mutations in LRRK2 are thus far the most common known cause of late-onset Parkinson’s disease (PD). The most prevalent LRRK2 mutation G2019S has been shown to stimulate LRRK2...

  • Understanding LRRK2 Biology, 2009
    Elucidating the Function and Downstream Targets of LRRK2

    Objective/Rationale
    One of the most exciting recent advances in PD research is that mutations within the gene coding for a protein of unknown function, LRRK2, predispose people to PD.  Since a number...

  • Understanding LRRK2 Biology, 2009
    LRRK2 in Neuronal Architecture

    Objective/Rationale
    Past observations in LRRK2 pre-clinical models have lead us to develop a unified hypothesis for LRRK2’s role in signaling/scaffolding and neuronal membrane dynamics. By utilizing...

  • Understanding LRRK2 Biology, 2009
    Investigating signaling pathway dysfunction linked to LRRK2

    Objective/Rationale
    Mutations in the gene LRRK2 are responsible for tens of thousands of cases of Parkinson’s disease, and are the most common genetic cause of this disease. At present we don’t...

  • Understanding LRRK2 Biology, 2009
    Biochemical Characterization of Full Length Human Recombinant LRRK1 and LRRK2

    Objective/Rationale
    Mutations in one gene, LRRK2, are a common cause of Parkinson’s disease.  However, the protein product of this gene is large and complex and, to date, no one has been able to make...

  • Understanding LRRK2 Biology, 2009
    LRRK2 Mediated Pathogenic Pathways in Dopaminergic Axonal Degeneration and Synaptic Transmission

    Objective/Rationale
    Mutations in the LRRK2 gene occur with high frequency in familial and sporadic Parkinson disease.  We have established a R1441G-LRRK2 transgenic pre-clinical model that...

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