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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Therapeutics Development Initiative, 2009
    Design of Neuroprotective Drugs to Reduce Oxidative Damage and Alpha-synuclein Toxicity in Parkinson's Disease

    Objective/Rationale:
    Exposure to chemical toxins that stimulate the production of reactive oxygen and nitrogen species (RONS) causes neuronal degeneration and can lead to Parkinson’s disease (PD)...

  • Therapeutics Development Initiative, 2009
    Developing Autophagy Enhancers as Disease-modifying Therapeutics for Parkinson's Disease

    Objective/Rationale:
    We seek to develop small molecule drugs that promote the cellular process of autophagy as disease-modifying therapy for Parkinson's disease (PD). Autophagy is a highly conserved...

  • Therapeutics Development Initiative, 2009
    Determination and Validation of the Molecular Target of J3, a Neuroprotective Lead Compound, for Its Optimization as a Disease-modifying Candidate for Parkinson's Disease

    Objective/Rationale:
    We have identified a small molecule, designated J3, which shows promising neuroprotection in an acute animal model of Parkinson’s disease (PD). To reach our ultimate goal of...

  • Biomarkers, 2009
    Development of an alpha6*-Selective Neuronal Nicotinic Receptor (NNR) Imaging Agent as a Parkinson's Disease Biomarker

    Objective/Rationale
    The availability of a selective PET radiotracer for the drug target is critical for determining receptor occupancy in humans. NNR subtypes containing the alpha? subunit have been...

  • Biomarkers, 2009
    High Resolution Diffusion Tensor Imaging in Parkinson's Disease and Parkinson Plus Syndromes

    Objective/Rationale
    An objective and valid trait and state biomarker of Parkinson’s disease will help therapeutic development by providing a measure to help confirm diagnosis (trait), and track...

  • Rapid Response Innovation Awards, 2009
    Possibility of Small Molecule Activation of PINK1 Kinase Activity

    Objective/Rationale
    Many genetic disorders are caused by the loss of a functional protein which protects cells from disease. These disorders are difficult to treat with drugs because most drugs block...

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