The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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MJFF Research Grant, 2004Simple Blood Tests for Parkinson's Disease Derived from Genome-wide Expression Changes
In work from their initial grant, Drs. Steven Gullans and Clemens Scherzer at Brigham and Women’s Hospital identified a number of genes that are differentially expressed in blood cells of patients...
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The Role of Inflammation in Parkinson's Disease, 2004The role of TNF-mediated dopaminergic neurotoxicity in Parkinson's disease: Novel anti-TNF biologics as biochemical tools and new therapeutic agents
In July 2004, at the one-year assessment of our initial grant under the Foundation's Inflammation initiative, we demonstrated that our novel dominant-negative TNFs offered significant in vivo...
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Community Fast Track, 2004Identification of Factors that Promote Midbrain Dopaminergic Fate from Embryonic Stem Cells and Neural Stem Cells
Parkinson's disease is a progressive neurological disorder caused by the degeneration of midbrain dopaminergic neurons. While cell transplantation has shown promising clinical benefit in some patients...
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Community Fast Track, 2004Characterization of DJ-1 Null Transgenic Mice
The protein DJ-1 has been implicated to play a role in neurodegenerative diseases, such as multiple system atrophy and Parkinson's disease (PD). Mutations in the DJ-1 gene have been linked to an...
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Community Fast Track, 2004The role of nociceptin/orphanin FQ in regulation of motor behavior and induction of parkinsonism
Nociceptin/orphanin FQ (N/OFQ) is an opioid-like neuropeptide discovered in the mid 90's, which activates a G-protein coupled receptor, the NOP receptor. N/OFQ and its receptor are diffusely expressed...
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Community Fast Track, 2004Engrailed as a Potential Therapeutic Target in Parkinson's Disease
Transcription factors constitute a class of molecules that regulate gene expression. Homeoproteins Engrailed-1 and Engrailed-2 (collectively Engrailed) are transcription factors expressed in the...
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Our funding programs support basic, translational and clinical research from academia and industry.