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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Improved Biomarkers and Clinical Outcome Measures, 2015
    Developing Progression Markers of Parkinson’s Disease with Multimodal Structural MRI of Substantia Nigra and Locus Coeruleus

    Study Rationale:
    Substantia nigra pars compacta (SNpc) and locus coeruleus (LC) are key brain areas involved in Parkinson’s disease. The loss of important chemicals (dopamine and norepinephrine) made...

  • Research Grant Supplement, 2015
    Identification of the Parkin-binding Domain for SLP-2 as a Potential Therapeutic Target Supplement

    Promising Outcomes of Original Grant:
    The objective of our Rapid Response Innovation Awards-supported project was to identify the parkin domain that interacts with Stomatin-like protein 2 (SLP-2), a...

  • Research Grant, 2015
    Nuclear Magnetic Resonance Analysis to Support Development of Alpha-Synuclein Imaging Agents

    Study Rationale:
    The Michael J. Fox Foundation Imaging Consortium has identified several promising compounds that bind specifically to alpha-synuclein fibrils, the clumps of protein that accumulate in...

  • Target Validation, 2015
    Transcription Factors as Key Targets to Regulate The Selective Vulnerability of Dopamine Neurons

    Study Rationale:                   
    Why specific subsets of brain cells such as those containing the chemical messenger dopamine are particularly vulnerable and degenerate is one of the central...

  • Research Grant, 2015
    CAPTURE-PD: Cutaneous Autonomic Pilomotor Testing to Unveil the Role of Neuropathy Progression in Early Parkinson’s Disease

    Study Rationale:                   
    Parkinson’s disease is a progressive neurodegenerative disorder that does not only affect movement but also the autonomic nervous system. Since most people start...

  • Research Grant Supplement, 2015
    Hit-to-Lead Optimization of Parkin Activators through Structure-Function Analyses

    Objective/Rationale:             
    This project aims to develop potent small molecule activators of Parkin, which is mutated in some forms of familial Parkinson’s disease and might also be inactivated...

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