Dr. Louis-Eric Trudeau is full professor of pharmacology, physiology and neurosciences at the University of Montreal Faculty of Medicine. His main research interests concern the mechanisms that control the connectivity and vulnerability of dopamine-containing neurons in the brain and the causes of Parkinson’s disease (PD). His laboratory has made numerous contributions to our understanding how dopamine neurons use glutamate as a co-transmitter, the functions of dopamine D2 autoreceptors and the origin of the selective vulnerability of dopamine neurons in PD. His current research focus includes uncovering the immune mechanisms involved in PD. Much of his research is aimed at identifying strategies to increase the resilience of dopamine neurons, to develop better animal models of PD and to identify new therapeutic approaches for this neurodegenerative disease. He has published more than 120 peer-reviewed articles.
Associated Grants
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Determining the Role of Proteins Associated with Parkinson’s Disease in T cell-Mediated Destruction of Dopamine Neurons
2024
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Role of PD-related Proteins as Drivers of Disease through Modulation of Innate and Adaptive Immunity
2020
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Transcription Factors as Key Targets to Regulate The Selective Vulnerability of Dopamine Neurons
2015
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Increased Dopamine Transporter Function as an Early Phenotype of PD, Prior to Dopamine Neuron Cell Death
2010