The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2014Role of LRRK2 in Dopamine Modulation of Striatal Glutamate Transmission
Objective/Rationale:
Many of the motor symptoms in Parkinson’s disease (PD) are attributed to a deficit of the neurotransmitter dopamine in the brain region called the striatum. Recent studies show... -
Target Validation, 2014CISD1 (mitoNEET) as a Mitochondrial Drug Target in Parkinson’s Disease
Objective/Rationale:
Mitochondrial dysfunction and oxidative stress contributes to the death of the brain cells seen in Parkinson’s disease. The mitochondrial protein mitoNEET (encoded by the gene... -
Parkin Therapeutic Development, 2014Pharmacological Modulation of Parkin Expression and Function to Attenuate Mitochondrial Dysfunction
Objective/Rationale:
This project aims to identify drug-like molecules that increase the amount of the protein parkin in neuronal cells. Parkin is mutated in some people with Parkinson’s disease (PD)... -
Rapid Response Innovation Awards, 2014Regulation of Alpha-synucleinopathy by BPOZ-2
Objective/Rationale:
BPOZ-2 is an anti-tumor protein that has been reported to stimulate the removal of cancer- related protein aggregates in cancer cells. However, its role has never been... -
Rapid Response Innovation Awards, 2014siRNA Screen of Microglia to Identify Neuroprotective Drug Targets in Parkinson´s Disease
Objective/Rationale:
Neuroinflammation is a fundamental process contributing to the death of neurons in Parkinson´s disease (PD). During this process, inflammatory microglia, which are the... -
Rapid Response Innovation Awards, 2014Mirtazapine as a Treatment for Pathological Gambling
Objective/Rationale:
Pramipexole (Mirapex®) is a drug that is effective at alleviating movement deficits associated with Parkinson’s disease. However, pramipexole can induce compulsive...
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Our funding programs support basic, translational and clinical research from academia and industry.