The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Synuclein Therapeutic Acceleration Program, 2013Pre-clinical Development of a Vaccine Against Alpha-synuclein Based on Virus-like Particles
Objective/Rationale:
Overexpression of the protein alpha-synuclein has been identified as a major cause for the development of Parkinson’s disease (PD) in humans. Lewy bodies, which... -
Synuclein Therapeutic Acceleration Program, 2013Development of the Alpha-Synuclein Stabilizer NPT200-11 for the Treatment of Parkinson’s Disease
Objective/Rationale:
A role for the synaptic protein alpha-synuclein in Parkinson’s disease is suggested by human genetic studies, the histopathology in patients with Parkinson’s disease and studies... -
Rapid Response Innovation Awards, 2013Alpha-Synuclein Effects on Fusion Pore Expansion and Protein Secretion
Objective/Rationale:
Alpha-synuclein, implicated in Parkinson’s disease, is normally expressed in nerve terminals, from which neurotransmitters are released by fusion of their granule membrane with the... -
Therapeutic Pipeline Program, 2013Synthetic Nurr1 Ligands as Novel Neuroprotective Therapeutics to Treat Parkinson’s Disease
Objective/Rationale:
The orphan nuclear receptor Nurr1 plays a critical role in the development and maintenance of midbrain dopamine neurons. Recent research also shows that it protects... -
Therapeutic Pipeline Program, 2013Novel, Small Molecule Transforming Growth Factor Beta Agonist
Objective/Rationale:
This project aims to develop a small molecule-based therapeutic targeting transforming growth factor beta (TGFB) signaling for the treatment of Parkinson’s disease (PD... -
LRRK2 Pharmacodynamic Assays, 2013Measuring LRRK2 Cellular Function in Parkinson’s iPSC-Derived Dopaminergic Neurons
Objective/Rationale:
We aim to develop a time-lapse, imaging, pharmacodynamic assay for measuring LRRK2 cellular function in dopaminergic (DA) neurons derived from human induced...
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Our funding programs support basic, translational and clinical research from academia and industry.