The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
-
Non-pharmacological Interventions for Gait and Balance, 2019Project Holocue: Smart Wearable Assistive Cueing Device for Reducing Freezing of Gait
Study Rationale:
Cues, such as stripes on the ground, may help alleviate and sometimes even prevent freezing of gait in people with Parkinson's disease. However, different people prefer different... -
Non-pharmacological Interventions for Gait and Balance, 2019Vibrating Socks: A Novel Cueing Intervention to Reduce Freezing of Gait in Parkinson's Disease
Study Rationale:
Freezing of gait is a common and disabling symptom in Parkinson's disease. With freezing of gait, patients have the feeling that their feet are suddenly glued to the floor when they... -
Biomarkers of Protein Handling/Autophagy, Exosomes and Lipid, 2019Studying Blood Proteins to Improve Diagnosis and Tracking of Parkinson's Disease
Study Rationale:
Mutations (changes) in protein LRRK2 is the main genetic cause of Parkinson's disease (PD). In the past, we found that LRRK2 interacts with ribosomes, cellular protein factories. We... -
GBA Biology and Therapies, 2019Resolving the Pathophysiology of Parkinson's Disease with GBA Mutations
Study Rationale:
Mutations in the GBA gene are the greatest genetic risk factor for developing Parkinson’s disease (PD). We will systematically examine pathophysiological pathways in PD patients with... -
GBA Biology and Therapies, 2019Identification of Targets of Neurotoxic Sphingolipids Using iPSCs from People with GBA-associated Parkinson’s Disease
Study Rationale:
GBA encodes the enzyme beta-glucocerebrosidase (GCase), which is required to maintain function of the cell’s lysosomes, which break down unnecessary cellular parts. Mutations in GBA... -
Alpha-Synuclein Biology and Therapies, 2019Development of a Novel Intracellular Alpha-synuclein-lowering Strategy based on CRISPR Interference Technology
Study Rationale:
Alpha-synuclein protein accumulates in the brain in Parkinson’s disease. Reducing the impact of this protein in the brain may prevent the degeneration of nerve cells and stop the...
Apply for a Grant
Our funding programs support basic, translational and clinical research from academia and industry.