The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutic Pipeline Program, 2021Proof of Concept and Translational Validation of USP30 to Offset Dysfunction in the PRKN Pathway
Study Rationale:
USP30 is an enzyme which acts in the opposite way to Parkin (PRKN), a gene linked to young-onset Parkinson’s disease (PD). Mutations in the PRKN gene impact mitochondria (the cell’s... -
Fall 2021 RFP: Accelerating Early Proof-of-Concept Testing of Promising PD Therapies, 2021Reprogramming the Brain’s Non-neuronal Support Cells to Generate Functional Dopamine-producing Neurons
Study Rationale:
We have recently demonstrated that a method for converting supportive, non-neuronal brain cells into functional dopamine-producing neurons leads to the complete reversal of symptoms... -
PIPETTE 4R Tau and Alpha-Synuclein PET Tracer Development, 2021San Antonio Ligand Consortium (SALC)
Study Rationale:
The development of alpha-synuclein and 4-repeat tau (4RT) positron-emission tomography (PET) imaging agents would benefit people with Parkinson’s disease (PD), progressive... -
Therapeutic Pipeline Program, 2021Using Virtual Reality to Understand and Treat Freezing of Gait
Study Rationale:
Freezing of gait, an episodic inability to initiate movement, is a leading reason for loss of independence in Parkinson’s disease (PD). Despite its prevalence, we lack an effective... -
Research Grant, 2021Tagging Genes Associated with Parkinson’s Disease Using the Gene-editing CRISPR Tool
Study Rationale:
Parkinson’s disease (PD) is caused, in part, by genetic alterations that produce defective proteins or perturb normal pathways in the brain. To determine how these alterations lead to... -
Analysis of Patient-Reported Outcomes from Fox Insight, 2021Investigation of Environmental Factors in Idiopathic and LRRK2-related Parkinson’s Disease
Study Rationale:
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by loss of neurons in the substantia nigra, a brain region that controls motion. This loss leads to...
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Our funding programs support basic, translational and clinical research from academia and industry.