The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Target Validation, 2010Does the Ubiquitin Ligase, Nedd4, Protect Against Alpha-Synucleinopathy?
Objective/Rationale:
The cellular mechanisms that normally limit accumulation of alpha-synuclein are unclear. We have found that the enzyme, Nedd4, tags alpha-synuclein for destruction in lysosomes... -
Rapid Response Innovation Awards, 2010Genetic Dissection of Parkinson's Disease Vulnerable Dopaminergic Neurons Population
Objective/Rationale:
There is a clear heterogeneity in the susceptibility of dopamine neurons to Parkinson’s disease. Indeed, neurons of the substancia nigra ventral tier are specifically lost in... -
MJFF Research Grant, 2010Clinical Assessment of Patients with PD Who Underwent DAT Scan and FDG PET at the Early Stages of Their Extra-Pyramidal Disorder as Part of Their Initial Workup
Objective/Rationale:
Ashkenazi Jewish PD patients in Israel have a 14% chance of carrying the G2019S LRRK2 mutation and 18% of carrying mutations in the GBA gene. Little is known on the association... -
MJFF Research Grant, 2010Delayed Start Assessment of Progranulin in a Progressive Rodent Model of Parkinson’s Disease
Promising Outcomes of Original Grant:
In preliminary development work, we demonstrated the capacity of the protein progranulin to protect against disease development in several pre-clinical model... -
MJFF Research Grant, 2010Coordinated Reset (CR) Stimulation of the Subthalamic Nucleus
Objective/Rationale:
Coordinated Reset (CR) stimulation improved locomotor activity in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP)-treated pre-clinical model in a “proof of concept” study... -
MJFF Research Grant, 2010Establishing an LRRK2 Signaling Pathway and Assays for Patient Derived Samples
Objective/Rationale:
Inherited mutations in a gene called LRRK2 have been found to cause Parkinson ’s disease. The LRRK2 gene encodes an enzyme called a kinase, for which no exact function has been...
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Our funding programs support basic, translational and clinical research from academia and industry.