The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
-
Therapeutics Development Initiative -- Academic Track, 2008Pre-clinical characterization of 5-HT1A/1B receptor agonists for the treatment of L-DOPA-induced dyskinesia
Objective/Rationale:
Levodopa, which is the most commonly used medication for patients with Parkinson's disease (PD), can cause, as the disease progresses, debilitating involuntary movements, so... -
Therapeutics Development Initiative -- Academic Track, 2008Novel alpha-Synuclein Isomers as Immunogens for Immunotherapy of Parkinson Diseases
Objective/Rationale:
The excessive accumulation of alpha-synuclein (a normal protein expressed in nervous system) in the brain has been shown to contribute to the pathogenesis of Parkinson disease (PD... -
Therapeutics Development Initiative -- Academic Track, 2008Characterization and validation of C. elegans LRRK2 model of PD
Objective/Rationale:
Autosomal dominant mutations in LRRK2 have been identified as a common cause for late-onset PD. Two of the most frequent PD-causing mutations, G2019S and R1441C, occur within the... -
Therapeutics Development Initiative -- Academic Track, 2008Effects of KCNQ (Kv7) Channel Openers in Levodopa-induced Dyskinesias
Objective/Rationale:
Retigabine, a novel well-tolerated antiepileptic drug with analgesic and anxiolytic effects, is an opener of neuronal Kv7 potassium channels. These channels (formely known as KCNQ... -
Therapeutics Development Initiative -- Academic Track, 2008Identification of a novel calcium selective antagonist for neuroprotection in PD
Objective/Rationale:
The objective of the project is to identify a selective and potent antagonist for the Cav1.3 L-type calcium channel. These channels are thought to be responsible for the selective... -
Therapeutics Development Initiative -- Academic Track, 2008Structural and Chemical Approaches to Understand and Modulate LRRK2 Kinase Activity in Parkinson's Disease
Objective/Rationale:
Mutations in LRRK2 cause the most common familial forms, and some sporadic forms, of Parkinson’s disease. Considerable evidence indicates that the neurotoxicity of these LRRK2...
Apply for a Grant
Our funding programs support basic, translational and clinical research from academia and industry.