The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Target Validation, 2015Validation of the Rip Kinase Pathway as a Therapeutic Target in Parkinson's Disease
Study Rationale:
A genetic connection has been shown over the past few years between Parkinson’s and Gaucher’s diseases, such that people with genetic mutations that cause Gaucher’s disease have a... -
Improved Biomarkers and Clinical Outcome Measures, 2015Validation of a Performance-based Assessment of Functional Ability Related to Cognition in Parkinson’s Disease
Study Rationale:
There is a pressing need for new treatments to address cognitive impairment in Parkinson’s disease, yet there is no consensus on how to best evaluate their... -
Target Advancement Program, 2015Study of the Molecular and Cellular Consequences of LRRK2 Kinase Inhibition in Neurons and Microglia
Study Rationale:
Mutations in leucine-rich repeat kinase-2 (LRRK2) are the greatest known genetic cause of Parkinson’s disease (PD). LRRK2 inhibitors may represent a new type of disease-modifying... -
Target Advancement Program, 2015LRRK2 and Insulin Signaling
Study Rationale:
Mutations in the LRRK2 gene may contribute to the development of familial and sporadic Parkinson’s disease (PD). Examination of the physiological role of the LRRK2... -
Therapeutic Pipeline Program, 2015Screening for Compounds Lowering Alpha-synuclein Expression Using a Novel Cell Line Assay
Study Rationale:
Multiple lines of evidence suggest that alpha-synuclein gain-of-function is characteristic of Parkinson’s disease (PD). Reduction of alpha-synuclein... -
Therapeutic Pipeline Program, 2015Assay-PoC for the Reduction of Endogenous Alpha-synuclein Levels in iPS-PD Neurons
Study Rationale:
Accumulation of the alpha-synuclein protein in the brain of individuals with Parkinson’s disease (PD) is a hallmark of the disease, and mutations in the...
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Our funding programs support basic, translational and clinical research from academia and industry.