The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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LRRK2 Role in Idiopathic Parkinson's Disease, 2014Deciphering the Genetic Architecture of the LRRK2 Gene in the Indian Population
Objective/Rationale:
Genetic variability in the LRRK2 gene is recognized as one of the most common cause of Parkinson’s disease (PD) mainly in the Caucasian, African-Arab, Ashkenazi Jewish and East... -
LRRK2 Role in Idiopathic Parkinson's Disease, 2014Assessing the Role of LRRK2 in Sporadic Parkinson’s Disease Using iPSC-derived Dopaminergic Neurons
Objective/Rationale:
Mutations in the LRRK2 gene are the greatest known contributors to genetic forms of Parkinson’s disease (PD). This project will investigate whether LRRK2 function also plays a role... -
Research Grant, 2014LRRK2 Expression in Postmortem Brain
Objective/Rationale:
Mutations in LRRK2 are a major genetic cause of Parkinson’s disease. This study aims to determine what happens to the amount of LRRK2 protein in the brains of people with Parkinson... -
Neurotrophic Factors Challenge, 2014Delivery of Cerebral Dopamine Neurotrophic Factor with Microbubbles and MRI-guided Focused Ultrasound
Objective/Rationale:
Neurotrophic drugs regenerate and protect brain cells damaged by Parkinson’s disease, but can’t penetrate the blood brain barrier (BBB). With direct needle or catheter drug... -
Research Grant, 2014Identification of Small Molecule Activators of Parkin Protein
Objective/Rationale:
Loss of parkin protein in humans leads to loss of dopamine neurons and ultimately Parkinson’s disease (PD). Loss of parkin activity is linked to young-onset familial PD, as well as... -
Research Grant Supplement, 2014PERK Signaling in Parkinson’s Disease Progression
Promising Outcomes of Original Grant:
The original study validated the role of PERK (protein kinase RNA-like endoplasmic reticulum kinase) signaling in the progression of Parkinson’s disease (PD). We...
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Our funding programs support basic, translational and clinical research from academia and industry.