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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • MJFF Research Grant, 2013
    Development of G2019S Selective LRRK2 Inhibitors for the Treatment of Parkinson’s Disease

    Objective/Rationale:             
    The LRRK2 kinase has been implicated as a potential therapeutic target for the treatment of Parkinson’s disease (PD). The goal of this project is to make experimental...

  • Rapid Response Innovation Awards, 2013
    Evaluation of Targeted Plasticity Therapy as a Treatment for Motor Dysfunction in Parkinson’s Disease

    Objective/Rationale:             

    Deterioration of motor function is a debilitating symptom of Parkinson’s disease (PD). We have recently developed a novel method that utilizes stimulation of the...

  • MJFF Research Grant, 2013
    Specific Modulation of Tau Oligomers by Passive Immunotherapy in a Parkinson's Disease Model

    Objective/Rationale: 
    The accumulation of tau protein is an important pathogenic factor in Parkinson’s disease (PD) and other neurodegenerative disorders. Our recent findings from pre-clinical models...

  • LRRK2 Challenge, 2013
    In Vivo Rescue of Dopamine Release Deficits via Kinase Inhibition in LRRK2 Mutant Mice

    Objective/Rationale:             
    Abnormal kinase activity is thought to be responsible for the pathogenic effects of LRRK2 in parkinsonian patients and many lines of evidence point towards a role of...

  • Research Grant, 2013
    Validation of Blood-borne Autoantibody Biomarkers for Parkinson’s Disease Supplement

    Promising Outcomes of Original Grant:
    The purpose of the original study was to determine if a small group of selected blood-borne autoantibody biomarkers that were previously shown to be effective in...

  • Research Grant, 2013
    Six-month Oral Toxicity Study of the Accordion Pill™ of Carbidopa/Levodopa

    Objective/Rationale:
    The Accordion Pill™ is designated to significantly stabilize the pharmacokinetic profile of drugs with a narrow absorption window, such as levodopa. Regular controlled-release...

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