The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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LRRK2 Pharmacodynamic Assays, 2013Fluorescence Fluctuation Spectroscopy Assays to Monitor the Activity of LRRK2
Objective/Rationale:
LRRK2 is a major protein target for therapeutic treatment of Parkinson’s disease (PD). The lack of assays (experiment set-ups) available for measuring the activity of... -
LRRK2 Cohort Consortium Resource Request, 2013Analysis and Replication of a Genetic Interaction between LRRK2 and PARK16
Study Rationale:
We previously showed that variants in two known Parkinson’s disease (PD) genes, LRRK2 and PARK16, genetically interact to increase risk of disease. Learning more about genetic variants... -
LRRK2 Cohort Consortium Resource Request, 2013Cortical and Subcortical Changes in Non-manifesting Carriers of the G2019S Mutation in the LRRK2 Gene
Objective/Rationale:
Imaging techniques such as DaT SPECT, FDG PET and magnetic resonance imaging (MRI) have frequently been used to assess Parkinson’s disease (PD) changes in parts of the brain called... -
LRRK2 Cohort Consortium Resource Request, 2013Influence of Immune Subtypes on the LRRK2 Phenotype
Study Rationale:
There is growing evidence for a relevant influence of chronic and subtle inflammation on Parkinson’s disease (PD). The most common causes of monogenic (involving one gene) PD are... -
Research Grant, 2013Lung Tissue Model
Study Rationale:
Organovo will leverage its tools and expertise as a 3D biology company to construct a lung model suitable for the screening of certain pharmaceutical compounds. Robust lab-based lung... -
Research Grant, 2013Evaluation of the RXR Agonist Compound IRX4204
Study Rationale:
Drugs that activate the retinoid X nuclear receptor (RXR) have been reported to promote survival of dopaminergic neurons in previously published pre-clinical studies. IRX4204 is a...
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Our funding programs support basic, translational and clinical research from academia and industry.